John M. Hickey (Author), Gregor Gorjanc (Author)

Abstract

An approach is described for simulating data sequence, genotype, and phenotype data to study genomic selection and genome-wide association studies (GWAS). The simulation method, implemented in a software package called AlphaDrop, can be used to simulate genomic data and phenotypes with flexibility in terms of the historical population structure, recent pedigree structure, distribution of quantitative trait loci effect, and with sequence and single nucleotide polymorphism-phased alleles and genotypes. Ten replicates of representative scenario used to study genomic selection in livestock were generated and have been made publically available. The simulated data sets were structured to encompass a spectrum of additive quantitative trait loci effect distributions, relastionship structures, and single nucleotide polymorpism chip densities.

Keywords

genomika;genomska selekcija;genotip;fenotip;simulacije;

Data

Language: English
Year of publishing:
Typology: 1.03 - Short Scientific Article
Organization: UL BF - Biotechnical Faculty
UDC: 575
COBISS: 3034248 Link will open in a new window
ISSN: 2160-1836
Views: 965
Downloads: 467
Average score: 0 (0 votes)
Metadata: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Other data

Secondary language: Unknown
Type (COBISS): Not categorized
Pages: str. 425-427
Volume: ǂVol. ǂ2
Issue: ǂno. ǂ4
Chronology: 2012
DOI: 10.1534/g3.111.001297
ID: 1033797