Matjaž Finšgar (Author), Amra Perva-Uzunalić (Author), Janja Stergar (Author), Lidija Gradišnik (Author), Uroš Maver (Author)

Abstract

Corrosion resistance, biocompatibility, improved osteointegration, as well the prevention of inflammation and pain are the most desired characteristics of hip replacement implants. In this study we introduce a novel multi-layered coating on AISI 316LVM stainless steel that shows promise with regard to all mentioned characteristics. The coating is prepared from alternating layers of the biocompatible polysaccharide chitosan and the non-steroid anti-inflammatory drug (NSAID), diclofenac. Electrochemical methods were employed to characterize the corrosion behavior of coated and uncoated samples in physiological solution. It is shown that these coatings improve corrosion resistance. It was also found that these coatings release the incorporated drug in controlled, multi-mechanism manner. Adding additional layers on top of the as-prepared samples, has potential for further tailoring of the release profile and increasing the drug dose. Biocompatibility was proven on human-derived osteoblasts in several experiments. Only viable cells were found on the sample surface after incubation of the samples with the same cell line. This novel coating could prove important for prolongation of the application potential of steel-based hip replacements, which are these days often replaced by more expensive ceramic or other metal alloys.

Keywords

korozija;hitozan;korozijska odpornost;biokompatibilnost;biomedicinski materiali;premazi;nerjaveče jeklo;corrosion;corrosion resistance;chitosan;biocompatibility;biomaterials;biomedical materials;coatings;stainless steel;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UM FKKT - Faculty of Chemistry and Chemical Engineering
UDC: 57.089:669.14.018.8
COBISS: 19591446 Link will open in a new window
ISSN: 2045-2322
Views: 1289
Downloads: 334
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Other data

Secondary language: Slovenian
Secondary keywords: korozija;hitozan;korozijska odpornost;biokompatibilnost;biomedicinski materiali;premazi;nerjaveče jeklo;
URN: URN:SI:UM:
Type (COBISS): Scientific work
Pages: str. 1-17
Volume: ǂVol. ǂ6
Issue: ǂart. no. ǂ26653
Chronology: Published online:24 May 2016
DOI: 10.1038/srep26653
ID: 10844202