vanadij

diplomsko delo univerzitetnega študijskega programa I. stopnje

Manca Merslavič (Author), Matjaž Finšgar (Mentor), Uroš Maver (Co-mentor)

Abstract

V diplomskem delu je predstavljena zasnova in analiza novih polimernih oblog, ki imajo vgrajene zdravilne učinkovine na zlitini Ti90/Al6/V4. Namen zasnove polimernih oblog je njihova potencialna uporaba v ortopedske (protetični implantanti – kolena, umetni kolki, ipd.) in zobozdravstvene namene. S pomočjo študije oblaganja vzorcev, karakterizacije tankih filmov in testiranja in vitro sproščanja, želimo spoznati možnost uporabe te zlitine v otropedski medicini, kjer bi se zdravilna učinkovina sproščala neposredno na določeno mesto in tako zagotovila ciljano sproščanje te učinkovine, prav tako pa bi bolniku pomagala pri okrevanju po operativnem posegu. Vgrajena zdravilna učinkovina sodi v skupino nesteroidnih protivnetnih učinkovin (NSAID). Rezultati študije karakterizacije vzorcev so pokazali prisotnost dveh glavnih komponent, to sta diklofenak in mešanica polimerov, kar smo potrdili s karakterizacijo tankih filmov z ATR-FTIR metodo, rezultati in vitro sproščanja pa so potrdili, da sproščanje zdravilne učinkovine vselej poteka po istem mehanizmu, in sicer v treh stopnjah: zelo hitro, hitro in zelo počasno sproščanje. Pritrdimo lahko, da se največ zdravilne učinkovine sprosti v prvih 360 minutah, kar prispeva k ciljanem odmerjanju le-te.

Keywords

zlitine;večslojne obloge;diklofenak;oblaganje z vrtenjem;in vitro sproščanje;diplomske naloge;

Data

Language:	Slovenian
Year of publishing:	2018
Typology:	2.11 - Undergraduate Thesis
Organization:	UM FKKT - Faculty of Chemistry and Chemical Engineering
Publisher:	[M. Merslavič]
UDC:	66.095.26:669.715(043.2)
COBISS:	21953302
Views:	840
Downloads:	83
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	English
Secondary title:	Development and analysis of novel polymeric coatings with integrated pharmaceutical substances on titanium/aluminium/vanadium alloy
Secondary abstract:	This bachelor thesis presents the design and analysis of new polymer coatings with integrated active substances on Ti90/Al6/V4 alloy. These polymer coatings have the potential for being used in orthopedic (prosthetic implants – artificial hips, knees, elbows, etc.) and dental purposes. With the help of case study on coating substrates, characterisation of thin films and testing in vitro release, we want to determine whether it is possible to use such materials in orthopedic medicine, where the active substance would be released directly onto specified location and thus ensure a targeted release of the substance and further also help a patient recover after surgical procedure. Integrated active substance belongs to the group of nonsteroidal anti-inflammatory drugs (NSAID). Results of the study on characterization of thin films showed presence of two main components: diclofenac and a mixture of polymers, which were confirmed with the characterization of thin films by ATR-FTIR method. The results of in vitro release state that the release of the active substance always takes place in the same mechanism in three stages: very fast release, fast release and very slow release. In conclusion, most of the active substance releases in the first 360 minutes, which contributes to targeted dosing.
Secondary keywords:	alloys;multilayer coatings;diclofenac;spin coating;simpin vitro release;
URN:	URN:SI:UM:
Type (COBISS):	Bachelor thesis/paper
Thesis comment:	Univ. v Mariboru, Fak. za kemijo in kemijsko tehnologijo
Pages:	VIII, 28 str.
ID:	10847203