Tanja Peric (Author), A. Comin (Author), M. Corazzin (Author), M. Montillo (Author), F. Canavese (Author), Marco Stebel (Author), A. Prandi (Author)

Abstract

The aim of this study was to assess hair cortisol concentrations in New Zealand white rabbits (Oryctolagus cuniculus) that were subjected to relocation and surgery to evaluate HPA-axis activity; in addition, we used this marker of cortisol secretion to evaluate the allostatic load of animals undergoing surgery. After a period of acclimatisation, which lasted 40 days from their arrival at the enclosure, 19 rabbits were subjected to T1–T12 dorsal arthrodesis (RS), 19 were sham-operated (SS), and 19 were non-operated (CON). Hair samples were collected at the time of arrival (ST1) at the animal facility, and seven other sets of hair samples were collected at 40-day intervals from the same area of skin for a period of 240 days as re-shaved hair (anagen phase): immediately before surgery (ST2) and after the surgery (ST3, ST4, ST5, ST6, ST7, and ST8). The transition from the rabbitry to the animal breeding facility led to a significant increase in cortisol concentration (ST2) in all of the groups. At ST3, the RS group presented higher cortisol concentrations than those of the SS group and the CON group. At ST4, the experimental groups showed similar values that remained constant until ST8. The results show that the management of rabbits undergoing surgery should be evaluated very carefully, and hair cortisol concentrations may provide a means of avoiding the dangerous cumulative effects of additional stressors close to surgery.

Keywords

cortisol;HPA axis;hair;rabbits;surgery;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UNG - University of Nova Gorica
UDC: 636.1/.9
COBISS: 5061115 Link will open in a new window
ISSN: 0962-7286
Views: 3386
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Other data

URN: URN:SI:UNG
Type (COBISS): Not categorized
Pages: str. 13-20
Volume: ǂVol. ǂ27
Issue: ǂno. ǂ1
Chronology: 2018
DOI: 10.7120/09627286.27.1.013
ID: 10904423
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