diplomsko delo
Urška Ušeničnik (Author), Peter Dovč (Mentor), Peter Dovč (Thesis defence commission member), Mojca Narat (Thesis defence commission member), Polona Jamnik (Thesis defence commission member)

Abstract

Prikazan je pomen uporabe mezenhimskih matičnih celic v terapiji različnih bolezni in poškodb kjer zaradi njihovega imunomodulatornega, antiapoptotičnega delovanja in diferenciacijskega potenciala pripomorejo k hitrejši regeneraciji. Za njihovo uspešno uporabo je potrebno znanje o postopkih izolacije, karakterizacije, diferenciacije in shranjevanja celic, ter o različnih dostavnih sistemih, ki se razlikujejo med različnimi terapijami. Diplomsko delo prav tako vsebuje prednosti in slabosti uporabe biomaterialov kot nosilcev pri različnih načinih aplikacije celic, ki lahko zaradi odprtega sistema pripomorejo k njihovemu boljšemu nadzoru in diferenciaciji. Na koncu je delovanje mezenhimskih matičnih celic pri psu prikazano na primeru osteoartritisa, periodontalnih bolezni, regeneracije kože, kroničnih poškodb, kroničnega vnetja črevesja in tumorja.

Keywords

biotehnologija;mezenhimske matične celice;maščobno tkivo;terapevtska uporaba;pes;biomateriali;bolezni;

Data

Language: Slovenian
Year of publishing:
Typology: 2.11 - Undergraduate Thesis
Organization: UL BF - Biotechnical Faculty
Publisher: [U. Ušeničnik]
UDC: 602.9:591.81(043.2)
COBISS: 8812921 Link will open in a new window
Views: 1192
Downloads: 316
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Other data

Secondary language: English
Secondary title: Therapeutic use of canine (Canis familiaris) adipose-derived mesenchymal stem cells
Secondary abstract: The importance of therapeutic use of mesenchymal stem cells is outlined through their immunomodulatory and antiapoptotic effects as well as differentiation potential, which all contribute to faster regeneration. For successful therapeutic use the knowledge about isolation of mesenchymal stem cells, their characterization, differentiation and preservation is needed. Due to their specific effects different application systems which are adapted to different therapies play an important role. Strengths and weaknesses of biomaterials for different applications are discussed as they can be beneficial because of better control over the cells and their differentiation in an open system. At the end the therapeutic effect of mesenchymal stem cells are presented in the case of osteoarthritis, periodontal disease, skin regeneration, chronical wounds, chronic bowel disease and tumor.
Secondary keywords: biotechnology;mesenchymal stem cells;adipose tissue;therapeutic use;canine;biomaterials;diseases;
Type (COBISS): Bachelor thesis/paper
Study programme: 0
Thesis comment: Univ. v Ljubljani, Biotehniška fak., Študij biotehnologije
Pages: VI, 18 str.
ID: 10910296