magistrsko delo
Tena Oreški (Author), Miroslav Petrovec (Reviewer), Tatjana Avšič-Županc (Mentor), Tatjana Vilibić-Čavlek (Co-mentor)

Abstract

Limfocitni horiomeningitis (LCM) je zoonoza, ki jo prenašajo glodavci. Rezervoar virusa LCM so hišne miši (Mus musculus), ki virus izloĉajo z urinom in iztrebki. Ljudje se navadno okuţijo z vdihavanjem aerosoliziranih izloĉkov glodavcev. Veĉina okuţb pri ljudeh poteka brez kliniĉnih znakov ali le z znaki gripi podobne bolezni, pri manjšini se razvije aseptiĉni meningitis. Okuţba z LCMV med noseĉnostjo lahko privede do hudih prirojenih malformacij ploda. Natanĉna razširjenost LCMV okuţbe ni znana. Okuţbi so izpostavljene predvsem osebe, ki pogosto prihajajo v stik z glodavci (gozdni delavci, lovci). Cilj raziskave je bilo ugotoviti prevalenco LCMV pri poklicno izpostavljenih in splošni populaciji na Hrvaškem. V raziskavo je bilo vkljuĉenih 338 posameznikov iz kontinentalnih Hrvaških ţupanij: 122 izpostavljenih oseb (gozdni delavci, lovci, osebe v stiku z glodavci v hiši ali okolici), 115 oseb iz splošne populacije ter 101 noseĉnica. Protitelesa IgG proti LCMV smo ugotovili pri 6,8 % (23/338) preiskovancev: pri 9,8 % (12/122) izpostavljenih oseb, pri 6,1 % (7/115) iz splošne populacije in 3,9 % (4/101) noseĉnic. Med seropozitivnimi je bilo 8,9 % (15/169) moških ter 4,7 % (8/169) ţensk. Ljudje iz primestnih/podeţelskih obmoĉij so bili pogosteje seropozitivni (9,2 %; 15/163) kot tisti iz mestnih obmoĉij (4,6 %; 8/175). Najveĉ seropozitivnih preiskovancev je bilo s podroĉja vzhodnih hrvaških ţupanij (8,3 %; 6/72), nato z obmoĉja Zagreba in osrednje Hrvaške (7,8 %; 15/214), najmanj pa na severozahodnem delu Hrvaške (3,8 %; 2/52). S statistiĉnimi metodami smo ugotovili da sta najpomembnejša riziĉna dejavnika za okuţbo z LCMV prisotnost glodalcev v hiši (okolici) in ĉišĉenje gnezda glodavcev (OR=2.962, 95%CI=1.019−8.607).

Keywords

virus limfocitnega horiomeningitisa;LCMV;glodavci;protitelesa;metoda posredne imunofluorescence;prekuženost;Hrvaška;

Data

Language: Slovenian
Year of publishing:
Typology: 2.09 - Master's Thesis
Organization: UL MF - Faculty of Medicine
Publisher: [T. Oreški]
UDC: 578.72:616.98:577.27.083.3
COBISS: 4887672 Link will open in a new window
Views: 1032
Downloads: 337
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Other data

Secondary language: English
Secondary title: Prevalence of lymphocytic choriomeningitis virus infection in Croatia
Secondary abstract: The main reservoirs of LCMV is house mouse (Mus musculus) that excrete virus in urine and stool. Humans are usually infected by inhalation of contaminated aerosol. In many infected individuals LCMV infection is asymptomatic or presented as a flu-like febrile disease, however some people develop aseptic meningitis. LCMV infection during pregnancy can cause severe congenital malformations. The exact prevalence of LCMV infection is unknown. The risk group include persons who are in contact with rodents (forest workers, hunters). The aim of the study was to determine the seroprevalence of LCMV in professionally exposed and unexposed persons in Croatia. The study included 338 participants from continental Croatian counties: 122 exposed persons (forest workers, hunters, people with rodent exposure in house/yard), 115 persons from general population and 101 pregnant women. The LCMV IgG antibodies were detected in 6,8 % (23/338) participants: 9,8 % (12/122) of exposed persons, 6,1 % (7/115) of the general population and 3,9 % (4/101) of pregnant women. According to gender, seropositivity was 8,9 % (15/169) in males and 4,7 % (8/169) in females. Residents of suburban/rural areas were more often seropositive (9,2 %; 15/163) than those from urban areas (4,6 %; 8/175). The highest number of seropositive subjects were from the eastern Croatian counties (8,3 %; 6/72), Zagreb and central Croatia (7,8 %; 15/214), and the lowest from northwestern Croatia (3,8 %; 2/52). The results of logistic regression have shown that the presence of rodents in the house/yard and cleaning rodents nests are the most significant risk factors for LCMV infection (OR=2.962, 95%CI=1.019−8.607).
Secondary keywords: lymphocytic choriomeningitis virus;LCMV;rodents;antibodies;immunofluorescence assay;prevalence;Croatia;
Type (COBISS): Master's thesis/paper
Study programme: 0
Embargo end date (OpenAIRE): 1970-01-01
Thesis comment: Univ. v Ljubljani, Biotehniška fak., Študij mikrobiologije
Pages: XI, 50 f., [1] f. pril.
ID: 10917000