diplomsko delo
Martin Bole (Author), Jernej Ogorevc (Mentor), Jernej Ogorevc (Thesis defence commission member), Mojca Narat (Thesis defence commission member), Polona Jamnik (Thesis defence commission member)

Abstract

Z izrazom pluripotentne matične celice označujemo nediferencirane celice, ki se lahko razvijejo v vse tri tipe zarodnih tkiv (endoderm, ektoderm in mezoderm), ne pa tudi v ekstra embrionalna tkiva. To pomeni sposobnost razvoja v več kot 200 različnih tipov celic. Njihova glavna značilnost je zmožnost neskončnega samoobnavljanja in vitro in plastičnost, saj preko celičnih delitev ne izgubijo potenciala za diferenciacijo v različne tipe tkiv. In vivo je pluripotentno stanje embrionalnih celic in je le kratko prehodno stanje v razvoju zarodka, ki nato vodi v nadaljno diferenciacijo celic in embrionalnih tkiv. Regulacija pluripotentnosti poteka na nivoju epigenetskih modifikacij, inhibicije z miRNA, različnih transkripcijskih faktorjev in majhnih molekul.

Keywords

matične celice;stanja pluripotence;epigenetika;transkripcijski faktorji;hranilna podlaga;

Data

Language: Slovenian
Year of publishing:
Typology: 2.11 - Undergraduate Thesis
Organization: UL BF - Biotechnical Faculty
Publisher: [M. Bole]
UDC: 602.9:611.018:591.81(043.2)
COBISS: 8983673 Link will open in a new window
Views: 963
Downloads: 303
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Other data

Secondary language: English
Secondary title: Regulation of pluripotency in stem cells
Secondary abstract: Pluripotent stem cells are undifferentiated cells, which can then evolve into all three germ layers (endoderm, ectoderm and mesoderm) but not to extraembryonic tissue. This means that they can differentiate into more than 200 types of cells. Their main characteristics is the ability to self-renew in vitro and their plasticity, as they do not lose the ability to differentiate even after multiple cell divisions. In vivo, pluripotency is a short transitional phase of the embryo, that then leads to further differentiation of cells and tissues. The cells regulate their pluripotency trough epigenetic modifications, miRNA interference, various transcriptional factors and small molecules.
Secondary keywords: stem cells;pluripotency states;epigenetics;transcriptional factors;feeder layer;
Type (COBISS): Bachelor thesis/paper
Study programme: 0
Thesis comment: Univ. v Ljubljani, Biotehniška fak., Študij biotehnologije
Pages: VIII, 25 str.
ID: 10939780