Ana Jeromen (Author), Irena Oblak (Author), Franc Anderluh (Author), Vaneja Velenik (Author), Marija Skoblar Vidmar (Author)

Abstract

Osnovno zdravljenje karcinoma želodca je radikalna resekcija. Ob postavitvi diagnoze je bolezen neresktabilna pri približno 50 % bolnikov. Znano je, da predoperativna radiokemoterapija lahko zmanjša tumor, kar povečuje možnost radikalne resekcije in podaljša preživetje teh bolnikov. V Sloveniji smo pri bolnikih z neresektabilnim nemetastatskim karcinomom želodca predoperativno radiokemoterapijo uvedli leta 2006. Uporabljamo 3-dimenzionalno konformalno načrtovanje obsevanja z računalniško tomografijo ter sočasno kemoterapijo s 5-FU in cisplatinom. Do sedaj je omenjeno zdravljenje prejelo 36 bolnikov. 19 bolnikov je bilo operiranih. Pri 12 (63 %) je bila bolezen odstranjena v celoti, pri 3 (16 %) je bil prisoten mikroskopski ostanek (R1 resekcija), pri 4 (21 %) pa je bil opravljen le paliativni poseg. Podrobnejša analiza bo opravljena po zdravljenju večjega števila bolnikov.

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Data

Language: Slovenian
Year of publishing:
Typology: 1.04 - Professional Article
Organization: OI - Institute of Oncology
UDC: 616.33-006.6-085
COBISS: 846459 Link will open in a new window
ISSN: 1408-1741
Parent publication: Onkologija
Views: 2437
Downloads: 545
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Secondary language: English
Secondary title: Preoperative radiochemotherapy for patients with unresectable stomach carcinoma
Secondary abstract: Radical resection is the basic treatment for stomach carcinoma. At the time of diagnosis, the disease is unresectable in nearly 50% of patients. It is known that preoperative radiochemotherapy can downstage the tumor and thereby allowing higher probability of radical resection and improving survival of patients. In 2006 preoperative radiochemotherapy was started in Slovenia for patients with non-metastatic unresectable stomach tumors. Three-dimensional conformal treatment planning with computer tomography and concomitant chemotherapy with 5-FU and cisplatin were used. So far, 36 patients received the above-mentioned treatment. In nineteen patients who were operated on so far, radical resection was performed in 12 (63%). In 3 (16%) patients microscopic residual disease (R1 resection) was found, and in 4 (21%) patients, only paliative surgery was performed. A detailed analysis of treatment success will be performed after obtaining the treatment results of greater number of treated patients.
Secondary keywords: Stomach neoplasms;Drug therapy;Radiotherapy;Preoperative care;Neoplasms metastasis;Radiotherapy, conformal;Želodec, novotvorbe;Zdravilo, terapija;Radioterapija;Predoperacijska nega;Novotvorba, metastaza;Radioterapija, konformalna;
URN: URN:NBN:SI
Pages: str. 93-94,150
Volume: ǂLeto ǂ13
Issue: ǂšt. ǂ2
Chronology: dec. 2009
ID: 10957293