diplomsko delo
Iva Levačić (Author), Bojan Knap (Reviewer), Irena Rogelj (Mentor)

Abstract

Za zdravje kože je zelo pomembno ravnotežje med mikrobioto kože in imunskim sistemom kože. Mikrobiota kože se razlikuje glede na različna območja in fiziološke značilnosti kože. Ob poškodbi kože nastopi mikrobna kolonizacija. Kolonizacija tkiva s škodljivimi mikroorganizmi sproži prirojen imunski odziv kože. Če pride do porušenja ravnotežja med mikrobioto kože in imunskim sistemom kože so večje možnosti za okužbe, celjenje ran pa je oteženo. Probiotiki lahko modulirajo tako mikrobioto kože kot tudi prirojen imunski sistem kože. Znanih je več mehanizmov delovanja probiotikov v povezavi z zaščito kože: modulacija imunskega sistema, tvorba protimikrobnih snovi, zaščita epitelne bariere in kompetativno izključevanje. Način in oblika modulacije imunskega sistema sta odvisna od probiotičnega mikroorganizma in se razlikujeta glede na vrsto in sev mikroorganizma. Na osnovi objavljenih in vitro ter kliničnih študij je dokazan pozitiven vpliv lokalne uporabe probiotičnih bakterijskih sevov na celjenje ran, izboljšanje atopične kože, zmanjšanje bakterijske obremenitve in spodbudujanje celjenja ran pri bolnikih z opeklinami, uspešno zdravljenje aken ter preprečevanje bakterijske vaginoze. Najbolj pogosti probiotični sevi za lokalno uporabo pripadajo bakterijskim vrstam Lactobacillus reuteri, L. plantarum, L. fermentum, L. rhamnosus, L. johnsonii, Bifidobacterium longum, Streptococcus thermophilus in Staphylococcus epidermis.

Keywords

probiotiki;koža;mikrobiota kože;okužbe;celjenje ran;

Data

Language: Slovenian
Year of publishing:
Typology: 2.11 - Undergraduate Thesis
Organization: UL BF - Biotechnical Faculty
Publisher: [I. Levačić]
UDC: 579.61:616.5
COBISS: 4949368 Link will open in a new window
Views: 903
Downloads: 281
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Other data

Secondary language: English
Secondary title: Local use of probiotics for infection and wound healing
Secondary abstract: For skin health, the balance between skin microbiota and the immune system of the skin is very important. The microbiota of the skin differs depending on the different areas and physiological characteristics of the skin. In case of skin damage, microbial colonization occurs. When colonizing of the tissue with harmful microorganisms occurs, a congenital immune response of the skin is triggered. If the balance between the microbiota of the skin and the immune system of the skin failed, there is a greater chance of infection, and wound healing is difficult. Probiotics can modulate both the microbiota of the skin and the innate immune system of the skin. Several mechanisms of probiotic activity for the prophylaxis of skin are known: modulation of immune system, production of antimicrobials, epithelial barrier protection, and competitive exclusion. The mode and form of the modulation of the immune system depends on the probiotic microorganism and varies according to the species and the strain of the microorganism. On the basis of published in vitro and clinical studies, the positive effect of local use of probiotic bacterial strains on wound healing, the improvement of atopic skin, the reduction of bacterial loading and the promotion of wound healing in patients with burns, the successful treatment of acne and the prevention of bacterial vaginosis has been demonstrated. The most common probiotic strains for topical use belong to the species Lactobacillus reuteri, L. plantarum, L. fermentum, L. rhamnosus, L. johnsonii, Bifidobacterium longum, Streptococcus thermophilus and Staphylococcus epidermis.
Secondary keywords: probiotics;skin;skin microbiota;infection;wound healing;
Type (COBISS): Bachelor thesis/paper
Study programme: 0
Thesis comment: Univ. v Ljubljani, Biotehniška fak., Oddelek za živilstvo
Pages: VIII, 26 f.
ID: 10959678