Stranski učinki ob zdravljenju rakavih bolezni z zaviralci tirozinskih kinaz

Abstract

Zaviralci tirozin-kinaz so multitarčna zdravila, ki prek zaviranja različnih celičnih procesov učinkujejo pri več vrstah rakavih boleznih. Čeprav so stranski učinki ob zaviralcih tirozinskih kinaz v splošnem prenosljivi, pa so lahko tudi resni in povzročajo nemalo preglavic bolnikom, ki prejemajo zdravila dolgotrajno. Pogosto je potrebno zmanjšanje odmerkov ali prehodna ukinitev, redkeje pa se odločimo za trajno prekinitev zdravljenja. Značilni so kožna toksičnost, kardiovaskularni zapleti, težave gastrointestinalnega trakta - predvsem diareja, nepravilno delovanje ščitnice in utrujenost ob zdravljenju rakave bolezni.

Keywords

tarčna zdravila;zaviralci tirozinskih kinaz;stranski učinki;

Data

Language:	Slovenian
Year of publishing:	2018
Typology:	1.04 - Professional Article
Organization:	OI - Institute of Oncology
UDC:	616-006
COBISS:	2990971
ISSN:	1408-1741
Parent publication:	Onkologija
Views:	2374
Downloads:	607
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	English
Secondary title:	Side effects of tyrosine kinase inhibitors in cancer treatment
Secondary abstract:	Tyrosine kinase inhibitors are multicentric drugs that inhibit different cellular processes and are effective in the treatment of many types of cancer. Although the side effects of tyrosine kinase inhibitors are generally tolerable, they may also be serious and cause numerous problems in patients receiving long-term medication. Dosage reductions or transient withdrawal are often required, but only rarely is the treatment permanently discontinued. Typical complications include skin toxicity, cardiovascular complications, problems in the gastrointestinal tract, in particular diarrhoea, thyroid malfunction, and treatment-specific fatigue. The present article lays out the most common side effects of treatment with tyrosine kinase inhibitors.
Secondary keywords:	targeted drugs;tyrosine kinase inhibitors;side effects;
URN:	URN:NBN:SI
Pages:	str. 24-27
Volume:	ǂLetn. ǂ22
Issue:	ǂšt. ǂ1
Chronology:	jun. 2018
DOI:	10.25670/oi2018-004on
ID:	10980178