Tihomir Tomašić (Author), Matic Mirt (Author), Michaela Barančokova (Author), Janez Ilaš (Author), Nace Zidar (Author), Päivi Tammela (Author), Danijel Kikelj (Author)

Abstract

Development of novel DNA gyrase B inhibitors is an important field of antibacterial drug discovery whose aim is to introduce a more effective representative of this mechanistic class into the clinic. In the present study, two new series of Escherichia coli DNA gyrase inhibitors bearing the 4,5-dibromopyrrolamide moiety have been designed and synthesized. 4,5,6,7-Tetrahydrobenzo[1,2-d]thiazole-2,6-diamine derivatives inhibited E. coli DNA gyrase in the submicromolar to low micromolar range (IC50 values between 0.891 and 10.4 microM). Their ''ring-opened'' analogues, based on the 2-(2-aminothiazol-4-yl)acetic acid scaffold, displayed weaker DNA gyrase inhibition with IC50 values between 15.9 and 169 microM. Molecular docking experiments were conducted to study the binding modes of inhibitors.

Keywords

antibacterial;DNA gyrase;docking;inhibitor;thiazole;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UL FFA - Faculty of Pharmacy
UDC: 543:615.015.8
COBISS: 4240753 Link will open in a new window
ISSN: 0968-0896
Views: 1140
Downloads: 790
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Other data

Secondary language: Slovenian
Type (COBISS): Scientific work
Embargo end date (OpenAIRE): 2019-01-01
Pages: str. 338-349
Volume: ǂVol. ǂ25
Issue: ǂiss. ǂ1
Chronology: 2017
DOI: 10.1016/j.bmc.2016.10.038
ID: 11043210