Obravnava onkoloških pacientov s kaheksijo

(diplomsko delo)

Ana Unger (Author), Jasmina Nerat (Mentor)

Abstract

Izhodišča: Kaheksija je opredeljena kot zapleten presnovni sindrom, ki ga opredeljuje progresivna izguba skeletne mišične mase, z ali brez izgube maščobnega tkiva. Zaradi kompleksnosti patofiziološkega procesa kaheksije je potreben multimodalni pristop, ki obsega več možnih načinov obravnavanja pacienta s kaheksijo. Namen zaključnega dela je predstaviti problematiko kaheksije pri onkoloških pacientih in možne načine obravnave onkološkega pacienta s kaheksijo. Raziskovalne metode: Uporabili smo deskriptivno metodo dela in sistematični pregled strokovne in znanstvene literature. Za prikaz poteka analize literature smo uporabili PRISMA diagram. Kriteriji za iskanje literature so vključevali aplikacijo vnaprej zastavljenih vključitvenih oziroma izključitvenih kriterijev. V podrobno analizo je bilo vključenih 15 člankov. Rezultati: Z analizo tuje strokovne literature smo spoznali, da je prehranska podpora izrednega pomena pri obravnavi onkoloških pacientov s kaheksijo, saj le-ta vodi v izboljšanje počutja, prav tako pa je osnova za posameznikovo toleriranje farmakološkega zdravljenja. Določene skupine zdravil so primerne za zdravljenje kaheksije, vendar so potrebne dodatne raziskave, ki bodo potrdile varnost in učinkovitost uporabe zdravil v klinični praksi. Telesne vadbe zaenkrat s strani raziskav ne moremo potrditi kot uspešne, saj večina teh pacientov zaradi zdravstvenega stanja ni zmožna sodelovati v takšnih raziskavah. Diskusija in zaključek: Kaheksija pri onkoloških pacientih je resen zdravstveni problem, saj je razlog za kar 20 % smrti pri pacientih z malignim obolenjem. Zaradi heterogenosti teh pacientov in velikega izpada pri randomiziranih kliničnih raziskavah, je otežkočeno priti do jasnih zaključkov o učinkovitosti določene obravnave.

Keywords

maligna obolenja;prehranska podpora;farmakološko zdravljenje;fizična vadba;multimodalni pristop;

Data

Language:	Slovenian
Year of publishing:	2019
Typology:	2.11 - Undergraduate Thesis
Organization:	UM FZV - Faculty of Health Sciences
Publisher:	[A. Unger]
UDC:	613.292:616-006(043.2)
COBISS:	2515876
Views:	688
Downloads:	133
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	English
Secondary title:	Treatment of patients with cancer cachexia
Secondary abstract:	Background: Cancer cachexia is defined as a complex syndrome characterised by an ongoing loss of skletal muscle mass, with or without loss of fat mass. Due to complexity of pathophysiological process of cachexia, multimodal approach is needed. The purpose of research is to present issues of cancer cachexia and possible approaches for patients with cancer cacxhexia. Research methods: We used the descriptive method and systematic review of professional and scientific literature. To depict the flow of analysis of literature we used PRISMA diagram. Criteria for searching eligible literature was based on predetermined inclusion and exclusion criteria. We included 15 articles in detailed analysis. Results: With analysis of literature we found out that the nutritional support has a key role in cancer cachexia treatment, because it affect general status of patient and it is a base for good tolerance of pharmacological treatment. There are many pharmacological managements eligible, but ther is a need for more clinical trials and studies with bigger population, that can validate efficiency and safety of mediactions in clincial practice. Exercise cannnot be validated as efficient in treatment of oncological patients. Discussion and conclusion: Cancer cachexia is a serious health problem and it is a reason for 20 % of deaths in patients with malignant illness. Due to heterogeneity of patients and frequent exclusion in randomized clinical trials, it is difficult to make clear conclusion.
Secondary keywords:	malignant ilness;nutritional support;pharmacological management;exercise;multimodal approach;
Type (COBISS):	Bachelor thesis/paper
Thesis comment:	Univ. v Mariboru, Fak. za zdravstvene vede
Pages:	IV, 31 f.
ID:	11160186