Sinteza fluoroforov s 4-aminobifenilnim skeletom

diplomsko delo

Aleš Marsel (Author), Martin Gazvoda (Mentor)

Abstract

Na podlagi molekulskih sond, ki kažejo ugodne optične in vezavne lastnosti na protein tau, smo zasnovali in z uporabo klasičnih in modernih sinteznih metod pripravili nove molekule z različnimi elektron-akceptorskimi skupinami. Prost tok elektronov od elektron-donorske do elektron-akceptorske skupine v novih spojinah obljublja ugodne optične lastnosti za fluorescenčno mikroskopijo, hkrati pa stranska veriga aminske skupine omogoča vključitev radioaktivnega fluora-18 in s tem uporabo pri slikanju s pozitronsko emisijsko tomografijo.

Keywords

organska sinteza;molekulske sonde;fluorofori;4-aminobifenil;elektron-akceptorske skupine;optične lastnosti;fluorescenčna mikroskopija;diplomska dela;

Data

Language:	Slovenian
Year of publishing:	2019
Typology:	2.11 - Undergraduate Thesis
Organization:	UL FKKT - Faculty of Chemistry and Chemical Technology
Publisher:	[A. Maresl]
UDC:	547.1(043.2)
COBISS:	1538326723
Views:	588
Downloads:	170
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	English
Secondary title:	Synthesis of fluorophores with a 4-aminobiphenyl skeleton
Secondary abstract:	Based on previous research on molecular probes with favorable optical and binding properties towards protein tau, we designed and using classic and modern synthetic methods prepared new molecules with different electron-accepting groups. Free flow of electrons from electron-donating to electron-accepting groups in new compounds promises good optical properties for fluorescence microscopy, while side chain of the amine group offers an option to add radioactive fluorine-18, for use in positron emission tomography imaging.
Secondary keywords:	synthesis;fluorophores;4-aminobiphenyl;
Type (COBISS):	Bachelor thesis/paper
Study programme:	1000373
Embargo end date (OpenAIRE):	1970-01-01
Thesis comment:	Univ. v Ljubljani, Fak. za kemijo in kemijsko tehnologijo, UNI Kemija
Pages:	24 str.
ID:	11217770