Rentgenska praškovna difrakcija protibolečinskih zdravil

diplomsko delo

Tjaša Koželj (Author), Anton Meden (Mentor)

Abstract

Rentgenska praškovna difrakcija je metoda, ki temelji na difrakciji rentgenske svetlobe na kristaliničnih trdninah. Vsaka kristalinična faza ima edinstven praškovni difraktogram, kar nam omogoča kvalitativno analizo. V diplomskem delu sem analizirala šestnajst različnih vzorcev protibolečinskih zdravil. Vzorce sem ustrezno pripravila za snemanje s praškovnim rentgenskim difraktometrom in podatke snemanja kvalitativno obdelala z računalniškimi programi. Glavni namen je bil identificirati zdravilne učinkovine ter pomožne snovi v protibolečinskih zdravilih. Zanimale so me razlike med zdravili z enako zdravilno učinkovino ter ali so prisotne še dodatne snovi, ki niso navedene na navodilih za ustrezno jemanje zdravil. S programom X'Pert HighScore Plus sem praškovne difraktograme primerjala med seboj in z analizo pridobila podatke o kristaliničnosti oziroma prisotnosti amorfne faze. S programom CSM sem ugotovila, da v analiziranih vzorcih večina uklonov pripada zdravilni učinkovini in le majhen delež pomožnim snovem. Posledično sem ugotovila, da so si praškovni difraktogrami protibolečinskih zdravil, ki vsebujejo enako zdravilno učinkovino zelo podobni glede na uklonske kote in intenzitete uklonskih maksimumov. Nekaterih vzorcev mi ni uspelo v celoti identificirati, saj so nekatere spojine prisotne v zelo majhnih količinah in posledično niso opazne na difraktogramih ali pa so navedene spojine amorfne in če jih je malo, se le-te ne bodo poznale na ozadju. Primerjava ugotovljene sestave vzorcev z deklaracijo na zdravilih je po pričakovanju pokazala ujemanje.

Keywords

protibolečinska zdravila;zdravilne učinkovine;pomožne snovi;kvalitativna fazna analiza;rentgenska praškovna difrakcija;diplomska dela;

Data

Language:	Slovenian
Year of publishing:	2019
Typology:	2.11 - Undergraduate Thesis
Organization:	UL FKKT - Faculty of Chemistry and Chemical Technology
Publisher:	[T. Koželj]
UDC:	543.442.3(043.2)
COBISS:	1538406595
Views:	2340
Downloads:	641
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	English
Secondary title:	X-Ray Powder Diffraction of Painkillers
Secondary abstract:	X-ray powder diffraction is a method, based on X-ray diffraction on crystalline solids. Each crystalline phase has a unique powder diffractogram, which enables us to perform qualitative analysis. In my research, I have analyzed sixteen different patterns of painkillers. I prepared the samples appropriately for recording with powder X-ray diffractometer and processed the recorded data qualitatively with computer programs. The main purpose was to identify active pharmaceutical ingredient and excipients in painkillers. I was interested in the differences between medicines with the same active pharmaceutical ingredient and whether there were any additional substances not listed in the instructions for proper use of medicines. With X'Pert HighScore Plus, I compared the powder diffraction patterns with each other and obtained data on the crystallinity or presence of the amorphous phase by analysis. With the CSM program, I found that in the samples analyzed, most of the diffraction patterns belong to the active pharmaceutical ingredient and only a small proportion to the excipients. As a result, I have found that powder diffraction patterns of painkillers containing the same active pharmaceutical ingredient are very similar. I was unable to identify some of the samples, as they were very poorly crystallized or amorphous. Comparison of the established composition of the samples with the declaration on the medicinal products showed an agreement as expected.
Secondary keywords:	X-ray powder diffraction;painkillers;active pharmaceutical ingredient;qualitative phase analysis;
Type (COBISS):	Bachelor thesis/paper
Study programme:	1000373
Embargo end date (OpenAIRE):	1970-01-01
Thesis comment:	Univ. v Ljubljani, Fak. za kemijo in kemijsko tehnologijo, UNI Kemija
Pages:	71 str.
ID:	11220300