diplomsko delo
Anja Rutar (Author), Blaž Cigić (Reviewer), Polona Jamnik (Mentor)

Abstract

Diplomsko delo obravnava področje nutrigenomike omega-3 maščobnih kislin in pojasnjuje, kako le-te vplivajo na izražanje genov in posledično bolezni kot so rak, srčno-žilne bolezni, vnetja in druge. Nutrigenomika nam omogoča globje razumevanje povezave med bioaktivnimi komponentami hrane in boleznimi že na ravni molekul in celičnih procesov. Omega-3 maščobne kisline so povezane z manjšim tveganjem za nekatere vrste raka, kar je povezano s citotoksičnim delovanjem na rakave celice, v katerih sprožijo proces apoptoze ali piroptoze, inducirajo oksidativni stres in povzročijo poškodbe DNA. Zmanjšujejo migracijo, invazijo in proliferacijo rakavih celic. V primeru vnetja pripomorejo k razrešitvi le-tega, saj zmanjšajo izražanje vnetnih, hkrati pa povečajo izražanje protivnetnih genov. Prav tako zmanjšajo znotrajcelično raven reaktivnih kisikovih zvrsti in so prekurzorji lipidnih mediatorjev s protivnetnim delovanjem, kar ugodno deluje na bolezni, kjer je vnetje podlaga le-teh (srčno-žilne bolezni, debelost in druge).

Keywords

nutrigenomika;genetika;prehranska genetika;prehranska genomika;omega-3 maščobne kisline;kronične nenalezljive bolezni;

Data

Language: Slovenian
Year of publishing:
Typology: 2.11 - Undergraduate Thesis
Organization: UL BF - Biotechnical Faculty
Publisher: [A. Rutar]
UDC: 612.3:575:641.1:613.2:547.915
COBISS: 5098360 Link will open in a new window
Views: 857
Downloads: 272
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Other data

Secondary language: English
Secondary title: Nutrigenomic effects of omega-3 fatty acids
Secondary abstract: The thesis addresses nutrigenomic effects of omega-3 fatty acids and explains how they affect the expression of genes and consequently affect many diseases such as cancer, cardiovascular disease, inflammation and others. Nutrigenomics gives us a deeper understanding of the link between bioactive food components and diseases at the level of molecules and cellular processes. Omega-3 fatty acids are associated with a lower risk for certain types of cancer as they have a cytotoxic effect on cancer cells in which they induce the process of apoptosis or pyroptosis, induce oxidative stress and cause DNA damage. They reduce migration, invasion and proliferation of cancerous cells. When it comes to inflammation, omega-3 fatty acids are involved in resolution of inflammation as they reduce the expression of inflammatory and in the same time increase the expression of anti-inflammatory genes. They also reduce intracellular levels of reactive oxygen species and are precursors of lipid mediators with anti-inflammatory actions, termed eicosanoids. Therefore they help in treatment of inflammation-associated diseases, such as cardiovascular disease, obesity and others.
Secondary keywords: nutrigenomics;genetics;nutritional genetics;nutritional genomics;omega-3 fatty acids;chronic noncommunicable diseases;
Type (COBISS): Bachelor thesis/paper
Study programme: 0
Embargo end date (OpenAIRE): 1970-01-01
Thesis comment: Univ. v Ljubljani, Biotehniška fak., Oddelek za živilstvo
Pages: VII, 22 f.
ID: 11224189