magistrsko delo
Miha Ivanetič (Author), Urška Šebenik (Mentor), Marjan Marinšek (Thesis defence commission member), Aleš Ručigaj (Thesis defence commission member)

Abstract

Sodobni trendi na področju industrije spodbujajo k uporabi obnovljivih in biorazgradljivih materialov, ki so trajnostni in imajo čim manjši vpliv na okolje. Ko je govora o materialih, se vse pogosteje posega na področje nanomaterialov, ki imajo izboljšane lastnosti in večjo aplikativno vrednost. Med temi materiali so hidrogeli na osnovi različnih polimerov, ki se v farmacevtski industriji uporabljajo za tarčno in kontrolirano sproščanje učinkovin v telesu. V sklopu magistrskega dela sem preučeval vpliv strukture hidrogelov na osnovi TEMPO modificirane nanofibrilne celuloze in skleroglukana na reološke lastnosti ter spremljal sproščanje nikotina iz teh hidrogelov. Ugotovil sem, da sta starost in koncentracija pomembna parametra, ki vplivata na strukturo hidrogelov, njun vpliv pa je mogoče preučevati preko reoloških lastnosti. Ugotovil sem, da je poleg strukture hidrogela ključen faktor pri sproščanju spojine interakcija med hidrogelom in spojino.

Keywords

nanomateriali;polimeri;hidrogeli;TEMPO modificirana nanofibrilna celuloza;skleroglukan;reologija;reološke lastnosti;sproščanje učinkovin;magistrska dela;

Data

Language: Slovenian
Year of publishing:
Typology: 2.09 - Master's Thesis
Organization: UL FKKT - Faculty of Chemistry and Chemical Technology
Publisher: [M. Ivanetič]
UDC: 678.5:620.3(043.2)
COBISS: 1538444483 Link will open in a new window
Views: 724
Downloads: 311
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Other data

Secondary language: English
Secondary title: Effect of composition of hydrogels from TEMPO-oxidized nanofibrillated cellulose and scleroglucan on rheological properties and compounds release
Secondary abstract: Current trends in industry promote use of renewable and biodegradable materials that are sustainable and have a minimal impact on the environment. When it comes to materials, there is an increasing involvement in the field of nanomaterials, which have improved properties and increased applicative value. Among these materials are hydrogels based on various polymers used in the pharmaceutical industry for targeted and controlled drug release. As part of my master's thesis, I studied the effect of composition of hydrogels from TEMPO-oxidized nanofibrillated cellulose and scleroglucan on rheological properties and release of nicotine from hydrogels based on these materials. I have concluded that ageing time and concentration are important parameters that affect the structure of hydrogels, and their influence can be studied through rheological properties. I have concluded that, in addition to the hydrogel structure, a key factor in the release of a compound is the interaction between the hydrogel and the compound.
Secondary keywords: hydrogels;TEMPO-oxidized nanofibrillated cellulose;scleroglucan;rheological properties;drug release;
Type (COBISS): Master's thesis/paper
Study programme: 1000376
Embargo end date (OpenAIRE): 1970-01-01
Thesis comment: Univ. v Ljubljani, Fak. za kemijo in kemijsko tehnologijo
Pages: 48 str.
ID: 11233705