magistrsko delo magistrskega študijskega programa II. stopnje Strojništvo
Gabriel Janič (Author), Iztok Golobič (Mentor), Matevž Zupančič (Co-mentor)

Abstract

V magistrskem delu smo obravnavali omočeno površino tabletnega jedra. Naša naloga je bila analizirati vplive disperzije pri različnih pogojih in parametrih, ko ta pride v stik s površino tabletnega jedra. Izvedli smo meritve kota omočenja in hitrosti kapilarnega vleka kapljice na površini tablete. Z nadgrajenim merilnim sistemom, ki je vključeval razpršilno šobo, optični mikroskop in hitro tekočo kamero, smo spremljali dogajanje na površini tablete med procesom tvorjenja filmske obloge. Koti omočenja pri neobloženi tableti z vodo so bili manjši kot pri neobloženi tableti s HPMC, za vodo so bili v območju 30-37° in za HPMC 80-87°. Hitrost kapilarnega vleka se z večanjem temperature povečuje in je pri treh različnih temperaturah 25 °C, 30 °C in 50 °C v območju 1,09-2,71 mm/s. Na osnovi opravljenih meritev smo ocenili, da so za tvorbo filmske obloge dane sestave ugodni naslednji pogoji: atomizacijski tlak 150 kPa, pretok 40 g/min, 10 % disperzija HPMC in temperatura 50 °C.

Keywords

magistrske naloge;omočena površina;meritve;tabletno jedro;velikost kapljic;hitra kamera;disperzija;

Data

Language: Slovenian
Year of publishing:
Typology: 2.09 - Master's Thesis
Organization: UL FS - Faculty of Mechanical Engineering
Publisher: [G. Janič]
UDC: 53.08:615.453.5(043.2)
COBISS: 17049371 Link will open in a new window
Views: 565
Downloads: 208
Average score: 0 (0 votes)
Metadata: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Other data

Secondary language: English
Secondary title: Analysis of the tablet film formation parameters
Secondary abstract: In the master's thesis we discussed the wetted surface of the tablet core. Our task was to analyse the effects of the dispersion under different conditions and parameters, when it comes in contact with the surface of the tablet core. Measurements of the wetting angle and velocity of the capillary traction of the droplet on the tablet surface were performed. With an upgraded measuring system that included a spray gun, an optical microscope and HighSpeed camera, we kept track of what was happening on the surface of the tablet during the film coating process. The wetting angles of the uncoated tablet with water, were smaller than those of the uncoated tablet with HPMC. For water, they were in the range of 30-37° and for the HPMC 80-87°. The velocity of the capillary traction increases with increasing temperature and is in the range of 1,09-2,71 mm/s at three different temperatures 25 °C, 30 °C in 50 °C. Based on the measurements taken, we estimated that for the formation of film coating compositions were given next favourable conditions: atomization pressure 150 kPa, flow 40 g/min, 10 % dispersion and 50 °C temperature.
Secondary keywords: master thesis;wetted surface;measurements;tablet core;droplet size;high speed camera;dispersion;
Type (COBISS): Master's thesis/paper
Study programme: 0
Embargo end date (OpenAIRE): 1970-01-01
Thesis comment: Univ. Ljubljana, Fak. za strojništvo
Pages: XXII, 60 str.
ID: 11411844
Recommended works:
, magistrsko delo magistrskega študijskega programa II. stopnje Strojništvo
, magistrsko delo magistrskega študijskega programa II. stopnje Strojništvo
, magistrsko delo magistrskega študijskega programa II. stopnje Strojništvo
, doktorsko delo
, magistrsko delo magistrskega študijskega programa II. stopnje Strojništvo