Tina Grapar Žargi (Author), Alan Kacin (Author)

Abstract

Po poškodbah in operativnih posegih mišično-skeletnih struktur je mišična atrofija s posledično oslabelostjo eden ključnih dejavnikov slabega funkcionalnega stanja pacientov. Na razvoj mišične atrofije med drugim vpliva tudi ishemično-reperfuzijska poškodba, ki nastane zaradi dolgotrajne ishemije med operativnim posegom. Kratkotrajne intermitentne zapore pretoka krvi z vmesnimi reperfuzijami izvedenimi pred ali po dolgotrajni ishemiji, tako imenovana ishemična priprava, imajo dokazano pozitivne vplive na zaščito skeletne mišice pred ishemično-reperfuzijsko poškodbo. Namen članka je sistematično pregledati znanstvene dokaze o zaščitnih učinkih različnih oblik ishemične priprave skeletnih mišic in predstaviti možnost njihove uporabe pred ali po operativnih posegih na zgornjih in spodnjih udih. Raziskave so pokazale zmanjšan odstotek odmrtja in poškodbe mišičnih celic ter boljše ohranjanje energetskih rezerv pri ishemično pred-pripravljenih preiskovancih. Dolgoročni vplivi ishemične priprave na razvoj atrofije in funkcijo mišice še niso raziskani, prav tako ni določen optimalen protokol, ki bi bil primeren za prenos v klinično prakso. Smiselno bi bilo raziskati dolgoročne vplive ishemične priprave z natančnimi meritvami prečnega preseka ali volumna mišic z magnetno resonanco in standardiziranimi testi mišične zmogljivosti in funkcije, ki bi jih bilo treba izvesti v ključnih časovnih intervalih po operativnem posegu.

Keywords

ishemična predpriprava;skeletna mišica;ishemično-reperfuzijska poškodba;

Data

Language: Slovenian
Year of publishing:
Typology: 1.02 - Review Article
Organization: UL ZF - University College of Health Studies
UDC: 615.8:616.74-007.23
COBISS: 4503403 Link will open in a new window
ISSN: 1318-2102
Views: 530
Downloads: 84
Average score: 0 (0 votes)
Metadata: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Other data

Secondary language: English
Secondary title: Ischemic conditioning of human skeletal muscle
Secondary abstract: Muscle atrophy and deconditioning are the major causes of poor functional status of patients following injuries or surgical procedures on musculoskeletal structures. Ischemia-reperfusion injury, caused by sustained ischemia during surgery, greatly influences the development of atrophy. Short termed periods of ischemia intermittent by reperfusion, so called ischemic conditioning, have been shown to attenuate the ischemia-reperfusion injury. The aim of this article is to systematically review scientific evidence of skeletal muscle protection induced by various protocols of ischemic conditioning and present potential protocols of its application before or after upper and lower limb surgery. Reviewed research presents evidence of increased cell viability, decreased cell injury and preservation of energy stores in preconditioned subjects. Despite the abundant evidence on acute protective effects, long-term effects of IP on development of muscle atrophy have not yet been investigated. There is clearly a need for determination of optimal IP protocol for clinical practice. Accurate measurements of cross-sectional area or muscle volume with magnetic resonance imaging, standardized muscle strength and function tests performed in crucial time intervals following surgery are the next logical step in the research of long-term effects of IP on human skeletal muscle.
Secondary keywords: ishemic preconditioning;skeletal muscle;ischemia-reperfusion injury;
URN: URN:NBN:SI
Pages: str. 48-55
Volume: ǂLetn. ǂ21
Issue: ǂšt. ǂ1
Chronology: 2013
ID: 11428667