magistrsko delo magistrskega študijskega programa II. stopnje Strojništvo
Valerija Javornik (Author), Iztok Golobič (Mentor), Matevž Zupančič (Co-mentor)

Abstract

V magistrskem delu smo opazovali površinska dogajanja na tableti glede na sočasen proces tvorjenja filmske obloge zaradi naprševanja kapljic in procesa sušenja tako nastale filmske obloge. Za analizo vpliva pretoka in deleža suhe snovi v disperzije ter začetne omočenosti tablete smo uporabili merilni sistem za razprševanje kapljic. Sestavljen je iz razpršilne šobe, optičnega mikroskopa ter hitrotekoče kamere. Omogoča nam spremljanje dogajanj na površini tablete. Na podlagi procesnih parametrov v farmacevtski industriji smo določili eksperimentalne pogoje oblaganja. Z razvitim eksperimentalnim sistemom smo analizirali dogajanje med procesom filmskega oblaganja tablete. Na obnašanje kapljic in posledično na tvorbo filmske obloge ima velik vpliv pretok disperzije in začetno stanje površine tablete pred razprševanjem. Na osnovi opravljenih meritev smo ocenili, da se enakomerna obloga se naredi pri razprševanju z 20 % disperzijo HPMC pri pršenju na golo tabletno jedro in pretokom 40 g/min. Povprečne velikosti kapljic se gibljejo v območju 40-90 [mikro] m.

Keywords

magistrske naloge;filmska obloga;omočena površina;analiza;sušenje;absorpcija;tabletno jedro;

Data

Language: Slovenian
Year of publishing:
Typology: 2.09 - Master's Thesis
Organization: UL FS - Faculty of Mechanical Engineering
Publisher: [V. Javornik]
UDC: 532.6:615.453.5(043.2)
COBISS: 18602755 Link will open in a new window
Views: 526
Downloads: 200
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Other data

Secondary language: English
Secondary title: Analysis of the surface events in the formation of a film coating of a tablet
Secondary abstract: In the master's theisis we observed surface events on the tablet according to the simultanious process of tablet film coating formation due to droplets spraying and drying process. To analyse the influence of the flow, the proportion of the dry matter in dispersion and initial wettness of the tablet we used measuring system for spraying droplets. It consists of spraying nozzle, optical mycroscope and fast running camera. It allowes us to monitor events on the tablet surface. Based on the process parameters in the pharmaceutical industry we determened experimental conditions of the coating. After the measurements we estimated that the flow of the dispersion and the initial state od the surface of the tablet have big influence on the droplets behaviour and consequently on film coating forming before spraying. We analysed the events durring film coating formation process with developed experimental system. The dispersion flow rate and the initial state of the tablet surface have a great influence on droplets behavior and consequently on a tablet film coating formation. Based on our measurements we estimated that an even coating is formed when we spray on the bare tablet core with 20% dispersion HPMC and flow rate of 40 g /min. Average droplets sizes are in the range of 40 to 90 [micro] m.
Secondary keywords: master thesis;film coating;wetted surface;analysis;drying;absorption;tablet core;
Type (COBISS): Master's thesis/paper
Study programme: 0
Embargo end date (OpenAIRE): 1970-01-01
Thesis comment: Univ. Ljubljana, Fak. za strojništvo
Pages: XXII, 56 str.
ID: 11769181
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