Access to novel drugs for non-small cell lung cancer in Central and Southeastern Europe
ǂa ǂ Central European Cooperative Oncology Group analysis
Abstract
Background. Treatment of non-small cell lung cancer (NSCLC) improved substantially in the last decades. Novel targeted and immune-oncologic drugs were introduced into routine treatment. Despite accelerated development and subsequent drug registrations by the European Medicinal Agency (EMA), novel drugs for NSCLC are poorly accessible in Central and Eastern European (CEE) countries. Material and Methods. The Central European Cooperative Oncology Group conducted a survey among experts from 10 CEE countries to provide an overview on the availability of novel drugs for NSCLC and time from registration to reimbursement decision in their countries. Results. Although first-generation epidermal growth factor receptor tyrosine kinase inhibitors were reimbursed and available in all countries, for other registered therapies - even for ALK inhibitors and checkpoint inhibitors in first-line - there were apparent gaps in availability and/or reimbursement. There was a trend for better availability of drugs with longer time from EMA marketing authorization. Substantial differences in access to novel drugs among CEE countries were observed. In general, the availability of drugs is not in accordance with the Magnitude of Clinical Benefit Scale (MCBS), as defined by the European Society for Medical Oncology (ESMO). Time spans between drug registrations and national decisions on reimbursement vary greatly, from less than 3 months in one country to more than 1 year in the majority of countries. Conclusion. The access to novel drugs for NSCLC in CEE countries is suboptimal. To enable access to the most effective compounds within the shortest possible time, reimbursement decisions should be faster and ESMO MCBS should be incorporated into decision making.
Keywords
nedrobnocelični rak pljuč;zdravljenje;nova zdravila;Srednja Evropa;Jugovzhodna Evropa;non-small cell lung cancer;treatment;novel drugs;Central Europe;Southeastern Europe;
Data
| Language: | English |
|---|---|
| Year of publishing: | 2020 |
| Typology: | 1.01 - Original Scientific Article |
| Publisher: | Wiley Periodicals, Inc. on behalf of AlphaMed Press |
| UDC: | 616-006 |
| COBISS: |
2048592241
|
| ISSN: | 1549-490X |
| Views: | 1200 |
| Downloads: | 653 |
| Average score: | 0 (0 votes) |
| Metadata: |
|
Other data
| Secondary keywords: | Carcinoma, non-small cell lung;Therapy;Europe;Eastern Europe;Drug therapy;Nedrobnocelični karcinom pljuč;Terapija;Evropa;Vzhodna Evropa;Terapija z zdravili; |
|---|---|
| Source comment: | Nasl. z nasl. zaslona; Opis vira z dne 6. 12. 2019; |
| Pages: | str. e598-e601 |
| Volume: | ǂVol. ǂ25 |
| Issue: | ǂiss. ǂ3 |
| Chronology: | Mar. 2020 |
| DOI: | 10.1634/theoncologist.2019-0523 |
| ID: | 11915344 |
Recommended works:
Access to novel drugs for non-small cell lung cancer in Central and Southeastern Europe
2020,
ǂa ǂ Central European Cooperative Oncology Group analysis
Non-small cell lung cancer in countries of Central and Southeastern Europe
2018,
diagnostic procedures and treatment reimbursement surveyed by the Central European Cooperative Oncology Group
NSCLC molecular testing in Central and Eastern European countries
2018,
no subtitle data available
Trans-esophageal endobronchial ultrasound-guided needle aspiration (EUS-B-NA)
2018,
ǂa ǂ road map for the chest physician
Sequential afatinib and osimertinib in patients with EGFR mutation-positive non-small-cell lung cancer
2020,
final analysis of the GioTag study