diplomsko delo univerzitetnega študijskega programa I. stopnje
Lara Metlika (Author), Uroš Potočnik (Mentor), Boris Gole (Co-mentor)

Abstract

Eno izmed obetavnejših bioloških zdravil za zdravljenje kronične vnetne bolezni je biološko zdravilo vedolizumab. Na žalost je neodziv na terapijo še vedno prisoten pri 1/3 bolnikov. Natančna napoved odzivnosti pred začetkom terapije bi bila zato zelo pomembna. V diplomskem delu je prikazan sistematski pregled literature. Iskanje PubMed je bilo izvedeno z vnaprej določenimi ključnimi besedami in izrazi, da se ugotovijo ustrezne študije o napovedovalcih odziva. V rezultatih so prikazani dobljeni tipi markerjev; proteinski, klinični, v povezavi z koncentracijo ter na ravni mRNA, ter medsebojne primerjave različnih vrednosti. Bolniki s hudo boleznijo ali predhodno izpostavljenostjo anti-TNF terapiji se manj verjetno odzovejo na vedolizumab. Prav tako so zanimivi proteinski markerji C-reaktiven protein, raven albumina ter fekalnega kalprotektina. Zaključimo, da je v prihodnje potrebnih še več študij ter bolj sistematičen pristop k iskanju biomarkerjev.

Keywords

kronična vnetna črevesna bolezen;Crohnova bolezen;ulcerozni kolitis;vedolizumab;odziv;napovedovalci odziva;diplomske naloge;

Data

Language: Slovenian
Year of publishing:
Typology: 2.11 - Undergraduate Thesis
Organization: UM FKKT - Faculty of Chemistry and Chemical Engineering
Publisher: [L. Metlika]
UDC: 615.015.1:616.34-002(043.2)
COBISS: 33448451 Link will open in a new window
Views: 698
Downloads: 54
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Other data

Secondary language: English
Secondary title: Biomarkers of response to vedolizumab in inflammatory bowel diseases patients
Secondary abstract: Vedolizumab represents one of the most promising biological medications used in the chronic inflammatory disease treatment. Unfortunately, 1/3 of the patients are still classified as non-responsive to the vedolizumab therapy. Therefore, it would be extremely important to determine the precise level of responsiveness before starting the therapy. The present diploma thesis examines a systematic literature review. PubMed search was carried out by means of the pre-defined key words and expressions in order to establish the relevant studies on predictors of response. The results show the types of markers obtained in various studies: protein markers, clinical markers, markers related to the vedolizumab concentration, and markers on mRNA level. The results also illustrate the comparison between different marker values which were given in different scientific articles. Patients with mild form of the disease and anti-TNF naive patients are more likely to respond to the vedolizumab therapy. The following protein markers have also proved to be very interesting: C-reactive protein as well as the levels of albumin and faecal calprotectin. In the end it can be concluded that further research as well as a more systematic approach to finding biomarkers are needed in the future.
Secondary keywords: Chronic inflammatory bowel disease;Crohn's disease;ulcerative colitis;vedolizumab;response;and predictors of response.;
Type (COBISS): Bachelor thesis/paper
Thesis comment: Univ. v Mariboru, Fak. za kemijo in kemijsko tehnologijo
Pages: X, 43 str.
ID: 11987062