diplomsko delo
Monika Šelekar (Author), Mojca Narat (Mentor), Mojca Narat (Thesis defence commission member), Polona Jamnik (Thesis defence commission member), Nataša Štajner (Thesis defence commission member)

Abstract

Rak pljuč je vodilni razlog smrti po svetu med rakavimi obolenji. Je pogosto pozno odkrita bolezen s slabo prognozo. Možnosti zdravljenja so odvisne od več dejavnikov, vključno z vrsto in stopnjo raka. Bolniki se lahko zdravijo s kemoterapijo, radioterapijo, kirurškimi posegi in ciljno terapijo; pogosto pa zdravljenje poteka s kombinacijo več različnih terapij. Tako kot pri drugih tipih rakavih obolenj pa tudi pri raku pljuč nove možnosti zdravljenja predstavlja imunoterapija. Potencial imunoterapije za zdravljenje se preiskuje v številnih kliničnih študijah, največji uspeh pa so pokazali inhibitorji imunskih kontrolnih točk. Med tem ko se imunoterapija, ki uporablja inhibitorje imunskih kontrolnih točk, že uporablja tudi v praksi, so druge terapije še v različnih stopnjah razvoja. Med temi so največji potencial pokazala antigen specifična cepiva, cepiva na osnovi tumorskih celic ter uporaba adaptivne celične terapije ter citokinov.

Keywords

rak pljuč;imunoterapija;cepiva;inhibitorji imunskih kontrolnih točk;od antigena neodvisna imunoterapija;

Data

Language: Slovenian
Year of publishing:
Typology: 2.11 - Undergraduate Thesis
Organization: UL BF - Biotechnical Faculty
Publisher: [M. Šelekar]
UDC: 602.68:606:616-006.6:615.371(043.2)
COBISS: 32257795 Link will open in a new window
Views: 322
Downloads: 67
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Other data

Secondary language: English
Secondary title: ǂThe ǂpotential of immunotherapies in the treatment of lung cancer
Secondary abstract: Lung cancer is the leading cause of death among cancers worldwide. It is often a late-detected disease with a poor prognosis. Treatment options depend on several factors, including the type and stage of the cancer. Patients can be treated with chemotherapy, radiotherapy, surgery, and targeted therapy; often, however, treatment is done with a combination of several different therapies. As with other types of cancer, immunotherapy is a new treatment option for lung cancer. The potential of immunotherapy for treatment is being investigated in many clinical studies, and the greatest success has been shown by immune checkpoints inhibitors. While immunotherapy using immune checkpoint inhibitors is already being used in practice, other therapies are still in various stages of development. Among these, antigen-specific vaccines, tumor cell-based vaccines, and the use of adaptive cell therapy and cytokines have shown the greatest potential.
Secondary keywords: lung cancer;immunotherapy;vaccines;immune checkpoint inhibitors;antigen independent immunotherapy;
Type (COBISS): Bachelor thesis/paper
Study programme: 0
Embargo end date (OpenAIRE): 1970-01-01
Thesis comment: Univ. v Ljubljani, Biotehniška fak., Študij biotehnologije
Pages: VII, 22 str.
ID: 12033172