Vpliv pektina in saharoze na sproščanje paracetamola iz ogrodnih tablet

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Language:	Slovenian
Year of publishing:	2014
Source:	Ljubljana
Typology:	2.09 - Master's Thesis
Organization:	UL FFA - Faculty of Pharmacy
Publisher:	[J. Rus]
UDC:	547.458.2+615.453(043.3)
COBISS:	3616881
Views:	1061
Downloads:	198
Average score:	0 (0 votes)
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Secondary language:	English
Secondary title:	ǂThe ǂinfluence of pectin and sucrose on the release of paracetamol from modified-release tablets
Secondary abstract:	Matrix tablet is an oral dosage form, which ensures prolonged release, most frequently by swelling of hydrophilic polymer when it comes in contact with gastric juice. While the tablet passes the gastrointestinal tract it is exposed to different conditions that could affect drug release. The release is also influenced by food and drinks one consumes. The main goal of this thesis was to define effects of different concentrations of sucrose and pectin in media on drug release from matrix tablets with hydroxypropylmethyl cellulose (HPMC). The experiments were performed on two different types of tablets, which we made ourselves. Tablets contained paracetamol as a model substance, microcrystalline cellulose, magnesium stearate and HPMC. One type of the tablets contained HPMC Metolose® 65SH-4000, and the other type contained HPMC Metolose® 90SH-100 000 SR. The experiments were performed on a flow-through system with glass beads. Aqueous medium contained 0,002 M HCl and sucrose and pectin in different concentrations and combinations. Media with sucrose contained sucrose in concentrations 150, 200, 250 or 300 g/L, the medium with pectin contained a concentration of pectin 5 g/L, and the combined media contained above cited concentrations of sucrose and pectin in concentrations 1, 2 or 5 g/L. We concluded that both types of HPMC react differently when the concentration of sucrose increases. HPMC Metolose® 65SH-4000 is more susceptible to increasing the concentration of sucrose; drug release from tablets was fast, starting at concentration of sucrose 200 g/L. HPMC Metolose® 90SH-100 000 SR tablets started to release faster at the concentration 300 g/L of sucrose in the medium. On one hand, adding only pectin to the medium at concentration 5 g/L did not affect the release from tablets with HPMC Metolose® 65SH-4000. On the other, this concentration of pectin slightly increased the release rate from tablets with HPMC Metolose® 90SH-100 000. The release of paracetamol in sucrose media was changed (for both types of tablets) when we added pectin. With increasing the concentration of pectin up to 2 g/L in sucrose media, the release rate of paracetamol decreased. Concentration 5 g/L of added pectin significantly slowed down the release.
Secondary keywords:	pectin sucrose matrix tablets hydroxypropylmethyl cellulose release;
Type (COBISS):	Master's thesis/paper
Thesis comment:	Univ. Ljubljana, Fak. za farmacijo
Pages:	III, 58 f.
ID:	12054664