magistrsko delo
Jan Kotnik (Author), Aleš Ručigaj (Mentor), Marjan Marinšek (Thesis defence commission member), Urška Šebenik (Thesis defence commission member)

Abstract

V okviru te magistrske naloge sem s kombiniranjem hidrogelov, pripravljenih iz različnih biopolimerov, poskušal vplivati na viskoznost, strižni modul in velikost mreže končnih hidrogelov, ki bi se nato lahko uporabili za kontrolirano sproščanje učinkovin. Za doseganje manjše velikosti mreže in boljših mehanskih lastnosti so bili hidrogeli zamreženi z uporabo raztopine kalcijevega klorida kot zamreževala. Z reološkimi meritvami sta bila za posamezne vzorce določena strižni modul in viskoznost. Preko dobljenih strižnih modulov je bila izračunana gostota vozlišč in v nadaljevanju še velikost hidrogelne mreže. Ker načrtovani testi sproščanja niso bili izvedeni, so bili difuzijski koeficienti izbranih modelnih učinkovin določeni zgolj teoretično preko matematičnih modelov.

Keywords

hidrogeli;biopolimeri;zamreževanje;reologija;reološke meritve;difuzijski koeficient učinkovine;kontrolirano sproščanje;magistrska dela;

Data

Language: Slovenian
Year of publishing:
Typology: 2.09 - Master's Thesis
Organization: UL FKKT - Faculty of Chemistry and Chemical Technology
Publisher: [J. Kotnik]
UDC: 678:544.773.432:532.135(043.2)
COBISS: 42043139 Link will open in a new window
Views: 453
Downloads: 181
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Other data

Secondary language: English
Secondary title: Effect of different biopolymer mixtures on the controlled drug release from crosslinked hydrogels
Secondary abstract: Whit in the scope of this master's thesis I tried to influence the viscosity, shear modulus and mesh size of the final hydrogel, which could then be used for controlled drug release, by combining hydrogels prepared from different biopolymers. To achieve a smaller mesh size and better mechanical properties, the hydrogels were crosslinked using calcium chloride solution as a crosslinker. Rheological measurements were used to determine the shear modulus and viscosity of every individual sample. The cross-link density was calculated via the obtained shear modules, followed by the mesh size of the hydrogel. Since the planned release tests were not performed, the diffusion coefficients of the selected model drug were determined only theoretically via mathematical models.
Secondary keywords: hydrogel;biopolymer;crosslinking;rheological measurements;drug diffusion coefficient;
Type (COBISS): Master's thesis/paper
Study programme: 1000376
Thesis comment: Univ. v Ljubljani, Fak. za kemijo in kemijsko tehnologijo
Pages: 54 str.
ID: 12238193