diplomski seminar na bolonjskem študijskem programu 1. stopnje Fizika
Tadej Emeršič (Author), Aleš Fajmut (Mentor)

Abstract

V seminarju obravnavamo mehanizme razvoja sile v gladki mišični celici dihalnih poti ob holinergični stimulaciji. Pri tem obravnavamo od kalcija odvisen razvoj sile, ki upošteva podroben opis od kalcija in kalmodulina odvisne aktivacije encima kinaze lahkih verig miozina in aktivnost fosfataze lahkih verig miozina. Obstoječi model nadgradimo z elementi, ki opisujejo viskoelastične lastnosti gladkih mišičnih celic arterij. Modelni rezultati napovejo zakasnitve v razvoju sile, kar je bolj v skladu z meritvami kot pri predhodnih modelih.

Keywords

viskoelastični modeli;izometrična kontrakcija;mišične celice;holinergične stimulacije;prečni mostički;kalcij;kalmodulin;kinaza lahkih verig miozina;diplomski seminarji;

Data

Language: Slovenian
Year of publishing:
Typology: 2.11 - Undergraduate Thesis
Organization: UM FNM - Faculty of Natural Sciences and Mathematics
Publisher: [T. Emeršič]
UDC: 53(043.2)
COBISS: 19345160 Link will open in a new window
Views: 398
Downloads: 10
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Other data

Secondary language: English
Secondary title: Viskoelastični model izometrične kontrakcije gladkih mišic
Secondary abstract: In this work we study mechanisms of stress development in an airway smooth muscle cell upon the cholinergic stimulation. In this case, the stress development is calcium dependent and includes activation of the calcium - calmodulin dependent myosin light chain kinase and activation of a myosin light chain phosphatase. The existing model is upgraded by the viscoelastic elements, that describe viscoelastic properties of smooth muscle cells of arteries. The model predicts a delay in the development of stress which gives better agreement with experimental results than the previous models.
Secondary keywords: viscoelastic model;isometric contraction;smooth muscle cell;cholinergic stimulation;cross bridge;calcium;calmodulin;myosin light chain kinase;
Type (COBISS): Final seminar paper
Thesis comment: Univ. v Mariboru, Fak. za naravoslovje in matematiko, Oddelek za fiziko
Pages: 21 f.
ID: 12528401