diplomsko delo
Raja Kužnik (Author), Hrvoje Petković (Mentor)

Abstract

Peptidi, predvsem speti in ciklični, so v zadnjem času vzbudili veliko zanimanja na področju razvoja biološko aktivnih učinkovin. Njihova prednost je majhna velikost, zmožnost prehajanja v celico, hkrati pa tudi visoka selektivnost vezave na tarčno molekulo ter zmožnost vplivanja na interakcije med proteini. Nove tehnologije na področju sintezne biologije omogočajo produkcijo velikih zbirk peptidnih molekul oz. peptidnih knjižnic ter hitro in učinkovito izbiranje peptidov z najboljšo afiniteto vezave na tarčo. Podjetje PeptiDream, katerega tehnologija je podrobneje opisana v tem diplomskem delu, je izpopolnilo pristope pridobivanja in izboljšave pripetih peptidov, njihovi produkti pa vstopajo v klinične študije.

Keywords

biološke učinkovine;aktivne učinkovine;peptidi;sinteza peptidov;pripeti peptidi;interakcije med proteini;razvoj zdravil;

Data

Language: Slovenian
Year of publishing:
Typology: 2.11 - Undergraduate Thesis
Organization: UL BF - Biotechnical Faculty
Publisher: [R. Kužnik]
UDC: 601.2:577.112.6(043.2)
COBISS: 70019843 Link will open in a new window
Views: 288
Downloads: 31
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Other data

Secondary language: English
Secondary title: New approaches for peptide design in the development of therapeutics
Secondary abstract: Peptides, especially constrained and cyclic peptides, are receiving increasing attention in drug discovery. Their advantages are small size, intracellular activity, as well as high selectivity of binding to the target molecule, and the ability to effect interactions between proteins. New synthetic biology technologies enable the production of large constrained peptide libraries and the rapid and efficient selection of peptides with high target binding affinity. The company PeptiDream, whose technology is described in this diploma work, has already established an effective technology for obtaining and improving constrained peptides, and a number of products are already entering clinical trials.
Secondary keywords: biologics;active substances;peptides;peptide synthesis;constrained peptides;protein interactions;drug development;
Type (COBISS): Bachelor thesis/paper
Study programme: 0
Embargo end date (OpenAIRE): 1970-01-01
Thesis comment: Univ. v Ljubljani, Biotehniška fak., Študij biotehnologije
Pages: VI, 20 str.
ID: 13112572