Emil Pal (Author), Miša Korva (Author), Katarina Resman Rus (Author), Nataša Kejžar (Author), Petra Bogovič (Author), Franc Strle (Author), Tatjana Avšič-Županc (Author)

Abstract

Hemorrhagic fever with renal syndrome (HFRS) is characterized by endothelial dysfunction with capillary leakage without obvious cytopathology in the capillary endothelium. The aim of the study was to analyze the kinetics of vascular endothelial growth factor (VEGF) and its soluble receptor (sVEGFR-2) in HFRS patients infected with Dobrava (DOBV) or Puumala virus (PUUV). VEGF and sVEGFR-2 levels were measured in daily plasma and urine samples of 73 patients with HFRS (58 with PUUV, 15 with DOBV) and evaluated in relation to clinical and laboratory variables. In comparison with the healthy controls, initial samples (obtained in the first week of illness) from patients with HFRS had higher plasma and urine VEGF levels, whereas sVEGFR-2 levels were lower in plasma but higher in urine. VEGF levels did not differ in relation to hantavirus species, viral load, or the severity of HFRS. The comparison of VEGF dynamics in plasma and urine showed the pronounced secretion of VEGF in urine. Significant correlations were found between daily VEGF/sVEGFR-2 levels and platelet counts, as well as with diuresis: the correlations were positive for plasma VEGF/sVEGFR-2 levels and negative for urine levels. In addition, patients with hemorrhagic manifestations had very high plasma and urine VEGF, together with high urine sVEGFR-2. Measuring the local secretion of sVEGFR-2 in urine might be a useful biomarker for identifying HFRS patients who will progress to severe disease.

Keywords

hemorrhagic fever;vascular endothelial growth factor;soluble receptor;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UL MF - Faculty of Medicine
UDC: 616.9
COBISS: 33775577 Link will open in a new window
ISSN: 2222-1751
Views: 436
Downloads: 99
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Other data

Secondary language: Slovenian
Secondary keywords: hemoragična mrzlica;vaskularni endotelijski rastni faktor;topni receptor;
Type (COBISS): Article
Source comment: V datoteki založnikove različice članka (PDF) je dodana uvodna stran, na kateri je kot založnik naveden Taylor and Francis. V samem članku je kot založnik naveden Nature (v glavi prve strani) oz. Springer Nature (na predzadnji strani pod naslovom Publisher's note). Pristajalna stran članka (URL) sodi med spletne strani založnika Taylor and Francis. (28. 7. 2021)
Pages: str. 1-9
Issue: ǂVol. ǂ7
Chronology: May 2018
DOI: 10.1038/s41426-018-0090-5
ID: 13177517