from model membranes to living organisms
Luka Kristanc (Author), Bojan Božič (Author), Špela Zemljič Jokhadar (Author), Marija Sollner Dolenc (Author), Gregor Gomišček (Author)

Abstract

The incidence of resistant fungal pathogens has been increasing, especially in immuno-compromised people. As such, considerable research has been focused on discovering anti-fungal agents with new mechanisms of action and on optimizing the use of existing agents. In this context, interest in the polyene group of anti-fungals has recently been renewed, since they are known to be effective against a broad spectrum of fungal pathogens that only rarely develop a resistance to them. In the past 10 years considerable efforts have been made to improve their efficacy and, simultaneously, to reduce their toxicity. Knowledge about the basic mechanisms of their action will be of crucial importance to further optimizing their use. The mechanisms of polyene action at the membrane level are reviewed here, focusing primarily on their pore-forming activity and on the resulting osmotic responses of artificial lipid vesicles and different eukaryotic cells.

Keywords

polyenes;sterols;pore forming;tension pore;osmotic stress;

Data

Language: English
Year of publishing:
Typology: 1.02 - Review Article
Organization: UL ZF - University College of Health Studies
UDC: 579+616
COBISS: 4634737 Link will open in a new window
ISSN: 0005-2736
Views: 339
Downloads: 85
Average score: 0 (0 votes)
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Other data

Secondary language: Slovenian
Secondary keywords: polieni;steroli;tvorjenje por;tenzijska pora;osmotski stres;Patogeni;
Type (COBISS): Article
Pages: str. 418-430
Volume: ǂVol. ǂ1861
Issue: ǂiss. ǂ2
Chronology: 2019
DOI: 10.1016/j.bbamem.2018.11.006
ID: 13181188