doktorska disertacija
Tomaž Omerzu (Author), Tanja Hojs-Fabjan (Mentor), Radovan Hojs (Co-mentor), Uroš Potočnik (Co-mentor)

Abstract

Multipla skleroza (MS) je kronična in vnetna bolezen osrednjega živčevja. Vnetje je prisotno v vseh stopnjah multiple skleroze in lahko povzroči dovzetnost za razvoj subklinične ateroskleroze. Ateroskleroza je zapleten proces z etiologijo, ki zajema več dejavnikov in vključuje vnetne, fibroproliferativne in angiogene odzive. Gre za kronični vnetni proces arterijske (žilne) stene in debelina karotidne intimne medije (IMT) velja za njen zgodnji označevalec. Namen te študije je bil primerjati subklinično aterosklerozo, vlogo vnetnih citokinov in pomen genetskih polimorfizmov med skupino bolnikov z recidivno-remitentno multiplo sklerozo (RR MS) in skupino zdravih posameznikov, ki so primerljivimi po starosti in spolu.

Keywords

multipla skleroza;ateroskleroza;debelina karotidne intime medije;cistatin C;intelevkin 6;genetski polimorfizmi;Bolezni živčevja;Disertacije;Multipla skleroza;Zapleti;Krvne žile;

Data

Language: Slovenian
Year of publishing:
Typology: 2.08 - Doctoral Dissertation
Organization: UM - University of Maribor
Publisher: T. Omerzu]
UDC: 616.832-002/-004+616.13-004.6:577.2.088(043.3)
COBISS: 95591171 Link will open in a new window
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Other data

Secondary language: English
Secondary title: SUBCLINICAL ATHEROSCLEROSIS IN PATIENTS WITH RELAPSING-REMITTING MULTIPLE SCLEROSIS – THE IMPORTANCE OF CLASSIC RISK FACTORS, INFLAMMATION AND GENETIC POLYMORPHISMS
Secondary abstract: Multiple sclerosis (MS) is an inflammatory disorder of central nervous system. Inflammation is present in all stages of multiple sclerosis and may create high susceptibility to subclinical atherosclerosis. Atherosclerosis is a complicated process with multifactorial etiology and involves inflammatory, fibroproliferative and angiogenic responses. It is a chronic inflammatory process of the arterial wall and carotid intima-media thickness (IMT) is regarded as its early marker. The purpose of this study was to compare subclinical atherosclerosis, the role of inflammatory cytokines and the role of genetic polymorphisms between the group of patients with relapsing-remitting multiple sclerosis (RRMS) and healthy controls matched for age and sex.
Secondary keywords: multiple sclerosis;atherosclerosis;carotid intima-media thickness;cystatin C;interleukin 6;genetic polymorphisms;Bolezni živčevja;Multipla skleroza;Ateroskleroza;Dejavniki tveganja (bolezni);
Type (COBISS): Dissertation
Thesis comment: Univ. v Mariboru, Medicinska fak.
Pages: XVI, 139 str.
ID: 13231356