Zdravljenje levkemije z limfociti [gama] [delta] T

diplomsko delo

Lana Groleger (Author), Mojca Narat (Mentor)

Abstract

Levkemija je pogost rak krvi in kostnega mozga, pri katerem pride do nenadzorovanega pomnoževanja belih krvnih celic oziroma levkocitov. V kostnem mozgu se tvori veliko število nefunkcionalnih in nepopolno razvitih belih krvničk, ki se sproščajo v kri in se nato prenesejo v ostale organe v telesu. Zaradi presežnega pomnoževanja levkocitov je v kostnem mozgu zmanjšano nastajanje drugih krvnih celic, tudi eritrocitov. Trenutno še ni zdravila, s katerim bi bolezen popolnoma pozdravili, vendar jo je možno obvladovati, da se ne vrne. Levkemične matične celice so zelo odporne, kar pojasni njihovo vztrajanje kljub uporabi večine tradicionalnih kemoterapevtikov. Vsak tip levkemije zahteva svoj način zdravljenja, vendar bi lahko z alternativnim pristopom zdravljenja z limfociti γδ T zdravili vse oblike rakavih obolenj. Za to vrsto celic je namreč značilno, da imajo več različnih mehanizmov aktivacije, torej imajo več neodvisnih sistemov za prepoznavanje tumorskih celic in mehanizmov delovanja proti njim.

Keywords

levkemija;krvne celice;limfociti gama delta T;homologna presaditev hematopoetskih matičnih celic;

Data

Language:	Slovenian
Year of publishing:	2021
Typology:	2.11 - Undergraduate Thesis
Organization:	UL BF - Biotechnical Faculty
Publisher:	[L. Groleger]
UDC:	606:616-006.6:616-008.853:611.018.46(043.2)
COBISS:	75647235
Views:	270
Downloads:	57
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	English
Secondary title:	Treatment of leukemia with [gama] [delta] T lymphocytes
Secondary abstract:	Leukemia is a common cancer of the blood and bone marrow, in which there is an uncontrolled multiplication of white blood cells or leukocytes. A large number of dysfunctional and imperfectly developed white blood cells are formed in the bone marrow, which are released into the blood and then transferred to other organs in the body. Excessive proliferation of leukocytes in the bone marrow reduces the production of other blood cells, including erythrocytes. There is currently no cure for the disease, but it can be controlled so that it does not return. Leukemic stem cells are highly resistant, which explains their persistence despite the use of most traditional chemotherapeutics. Each type of leukemia requires its own treatment, but all forms of cancer could be treated with an alternative approach to γδ T lymphocyte therapy. This type of cell is characterized by several different mechanisms of activation, ie they have several independent systems for recognizing tumor cells and mechanisms of action against them.
Secondary keywords:	leukemia;blood cells;gama delta T lymphocytes;homologous hematopoietic stem cell transplantation;
Type (COBISS):	Bachelor thesis/paper
Study programme:	0
Thesis comment:	Univ. v Ljubljani, Biotehniška fak., Študij biotehnologije
Pages:	VI, 18 str.
ID:	13335653