diplomsko delo
Leja Jelenko (Author), Janez Košmrlj (Mentor)

Abstract

Alzheimerjeva bolezen je ena izmed najbolj raziskovanih nevrodegenerativnih bolezni. Gre za progresivno nevrološko motnjo, ki zmanjša velikost možganov in vodi k odmrtju možganskih celic. Fluorescenčne sonde se pogosto uporabljajo v kliničnih raziskavah in diagnozi Alzheimerjeve bolezni. V tem delu je predstavljena sinteza dveh derivatov naftola, katerih optične lastnosti bi lahko s pridom uporabljali na različnih področjih znanosti. Gre za 6-acetil-2-(dimetilamino)naftalen in 1-{6-[(2-hidroksietil)(metil)amino]-2-naftil}etanon, oba sintetizirana iz 1-(6-hidroksinaftalen-2-il)etanona.

Keywords

Alzheimerjeva bolezen;organska sinteza;fluorescenčne sonde;naftolni derivati;Heckova reakcija;Buchererjeva reakcija;diplomska dela;

Data

Language: Slovenian
Year of publishing:
Typology: 2.11 - Undergraduate Thesis
Organization: UL FKKT - Faculty of Chemistry and Chemical Technology
Publisher: [L. Jelenko]
UDC: 547.593(043.2)
COBISS: 79744771 Link will open in a new window
Views: 232
Downloads: 53
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Other data

Secondary language: English
Secondary title: Synthesis and application of 2-naphthol derivative
Secondary abstract: Alzheimer disease is one of the most researched neurodegenerative diseases. It is a progressive neurological disorder that reduces the size of the brain and leads to the death of brain cells. Fluorescent probes are widely used in clinical trials and the diagnosis of Alzheimer disease. This thesis presents the synthesis of two naphthol derivatives, optical properties of which could be used to advantage in various fields of science. These are 6-acetyl-2-(dimethylamino)naphthalene and 1-{6-[(2-hydroxyethyl)(methyl)amino]-2-naphthyl}ethanone, both synthesized from 1-(6-hydroxynaphthalen-2-yl)ethanone.
Secondary keywords: Alzheimer disease;naphthol derivatives;synthesis;Heck reaction;Bucherer reaction;
Type (COBISS): Bachelor thesis/paper
Study programme: 1000373
Embargo end date (OpenAIRE): 1970-01-01
Thesis comment: Univ. v Ljubljani, Fak. za kemijo in kemijsko tehnologijo, UNI Kemija
Pages: 33 str.
ID: 13342311