diplomsko delo
Abstract
Pirazoloni in njihovi derivati so zaradi številnih bioloških aktivnosti in strukturnih lastnosti zelo pomembne potencialne učinkovine v medicini, agrokemiji in farmaciji. Kiralni derivati morajo imeti točno določeno stereokemijo, zato pri sintezi uporabljamo različne (organo)katalizatorje. V diplomskem delu najprej v uvodu predstavim zgodovino organokatalize, navedem vrste organokatalizatorjev in opišem delitev organokatalize. Nato predstavim pirazolon, njegove sintetizirane in naravne derivate ter njihovo uporabo. V 3. poglavju opišem sinteze najznačilnejših derivatov pirazolonov. V 4. poglavju naredim pregled znanih organokataliziranih pretvorb derivatov pirazolonov z različnimi reaktanti, opišem optimalne reakcijske pogoje, organokatalizatorje, izkoristke in stereoselektivnosti pretvorb. V zaključku naredim povzetek organokataliziranih pretvorb derivatov pirazolonov in vseh navedenih organokatalizatorjev v diplomskem delu.
Keywords
pirazoloni;organokataliza;organokatalizirane pretvorbe;stereoselektivna sinteza;Mannichova reakcija;Michaelova reakcija;diplomska dela;
Data
Language: |
Slovenian |
Year of publishing: |
2021 |
Typology: |
2.11 - Undergraduate Thesis |
Organization: |
UL FKKT - Faculty of Chemistry and Chemical Technology |
Publisher: |
[N. Metelko] |
UDC: |
547.78.057(043.2) |
COBISS: |
83308291
|
Views: |
254 |
Downloads: |
38 |
Average score: |
0 (0 votes) |
Metadata: |
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Other data
Secondary language: |
English |
Secondary title: |
Pyrazolone synthesis and their application in organocatalyzed transformations |
Secondary abstract: |
Due to their numerous biological activities and structural properties pyrazolones and their derivatives are very important potential active ingredients in medicine, agrochemistry and pharmacy. Chiral derivatives must have a specific stereochemistry, so we need to use a specific (organo)catalyst for their synthesis. In the thesis, I first present the history of organocatalysis in the introduction, list the types of organocatalysts and describe the division of organocatalysis. Then I present pyrazolone, its synthesized and natural derivatives and their use. In the third chapter, I describe the syntheses of the most characteristic pyrazolone derivatives. In the fourth chapter, I review the known organocatalyzed conversions of pyrazolone derivatives with different reactants, describe the optimal reaction conditions, organocatalysts, yields and stereoselectivity of conversions. In conclusion, I make a summary of organocatalyzed conversions of pyrazolone derivatives and all listed organocatalysts in the thesis. |
Secondary keywords: |
pyrazolone;organocatalysis;stereoselective synthesis;Mannich reaction;Michael reaction; |
Type (COBISS): |
Bachelor thesis/paper |
Study programme: |
1000373 |
Embargo end date (OpenAIRE): |
1970-01-01 |
Thesis comment: |
Univ. v Ljubljani, Fak. za kemijo in kemijsko tehnologijo, UNI Kemija |
Pages: |
39 str. |
ID: |
13381028 |