Youssef Dgachi (Author), Oscar M. Bautista-Aguilera (Author), Mohamed Benchekroun (Author), Hélène Martin (Author), Alexandre Bonet (Author), Damijan Knez (Author), Fakher Chabchoub (Author), José Marco-Contelles (Author), Lhassane Ismaili (Author), Justyna Godyń (Author), Barbara Malawska (Author), Stanislav Gobec (Author), Mourad Chioua (Author), Jana Janockova (Author), Ondrej Soukup (Author)

Abstract

We report herein the straightforward two-step synthesis and biological assessment of novel racemic benzochromenopyrimidinones as non-hepatotoxic, acetylcholinesterase inhibitors with antioxidative properties. Among them, compound 3Bb displayed a mixed-type inhibition of human acetylcholinesterase (IC50 = 1.28 % 0.03 microM), good antioxidant activity, and also proved to be non-hepatotoxic on human HepG2 cell line.

Keywords

Alzheimer's disease;quinazolinones;multicomponent reactions;multitarget-directed ligands;antioxidants;cholinesterase inhibitors;hepatotoxicity;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UL FFA - Faculty of Pharmacy
UDC: 615.2:616.894
COBISS: 4083825 Link will open in a new window
ISSN: 1420-3049
Views: 207
Downloads: 96
Average score: 0 (0 votes)
Metadata: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Other data

Secondary language: Slovenian
Secondary keywords: Alzheimerjeva bolezen;
Type (COBISS): Article
Pages: str. 1-15
Volume: ǂVol. ǂ21
Issue: ǂiss. ǂ5
Chronology: 2016
DOI: 10.3390/molecules21050634
ID: 13390858