Youssef Dgachi (Author), Oscar M. Bautista-Aguilera (Author), Mohamed Benchekroun (Author), Hélène Martin (Author), Alexandre Bonet (Author), Damijan Knez (Author), Justyna Godyń (Author), Barbara Malawska (Author), Stanislav Gobec (Author), Mourad Chioua (Author), Jana Janockova (Author), Ondrej Soukup (Author), Fakher Chabchoub (Author), José Marco-Contelles (Author), Lhassane Ismaili (Author)

Abstract

We report herein the straightforward two-step synthesis and biological assessment of novel racemic benzochromenopyrimidinones as non-hepatotoxic, acetylcholinesterase inhibitors with antioxidative properties. Among them, compound 3Bb displayed a mixed-type inhibition of human acetylcholinesterase (IC50 = 1.28 % 0.03 microM), good antioxidant activity, and also proved to be non-hepatotoxic on human HepG2 cell line.

Keywords

Alzheimer's disease;quinazolinones;multicomponent reactions;multitarget-directed ligands;antioxidants;cholinesterase inhibitors;hepatotoxicity;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UL FFA - Faculty of Pharmacy
UDC: 615.2:616.894
COBISS: 4083825 Link will open in a new window
ISSN: 1420-3049
Views: 207
Downloads: 96
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Other data

Secondary language: Slovenian
Secondary keywords: Alzheimerjeva bolezen;
Type (COBISS): Article
Pages: str. 1-15
Volume: ǂVol. ǂ21
Issue: ǂiss. ǂ5
Chronology: 2016
DOI: 10.3390/molecules21050634
ID: 13390858