Maja Zakošek (Author), Sonja Prpar (Author), Malan Štrbenc (Author), Urban Košak (Author), Ilija Ilić (Author), Jurij Trontelj (Author), Simon Žakelj (Author), Stanislav Gobec (Author), Darja Pavlin (Author), Gregor Majdič (Author)

Abstract

Canine cognitive dysfunction (CCD) is common in aged dogs and has many similarities with Alzheimer’s disease. Unfortunately, like Alzheimer’s disease, CCD cannot be cured. In the present study, we treated dogs with CCD with our newly developed and characterized butyrylcholinesterase inhibitor (BChEi). Seventeen dogs were randomized into two groups (treated with BChEi and untreated) and followed for 6 months at regular check-ups. The dogs’ cognitive status was determined by a Canine Dementia Scale (CADES) questionnaire and two cognitive tests. In dogs with moderate cognitive impairment, treatment caused significant improvement in the clinical rating of cognitive abilities and the performance-based tests of cognitive functioning when compared to the untreated group (p < 0.001). Dogs treated with BChEi showed markedly improved cognitive function with enhanced quality of life. No side effects were observed in the treated dogs with moderate cognitive impairment. According to the results of this preliminary study, there is an indication that novel BChEi may be a promising drug for the treatment of CCD in dogs and may be an interesting candidate for the treatment of Alzheimer's disease in humans. However, further clinical studies are needed to confirm this.

Keywords

Alzheimer’s disease;butyrylcholinesterase;butyrylcholinesterase inhibitor;canine cognitive dysfunction;canine dementia scale;dogs;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UL VF - Veterinary Faculty
UDC: 636.09:616
COBISS: 77000195 Link will open in a new window
ISSN: 2045-2322
Views: 226
Downloads: 62
Average score: 0 (0 votes)
Metadata: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Other data

Secondary keywords: Cognitive Dysfunction;Butyrylcholinesterase;Dogs;
Type (COBISS): Article
Pages: str. [1-10]
Volume: art. 18098
Issue: ǂVol. ǂ11
Chronology: 2021
DOI: 10.1038/s41598-021-97404-2
ID: 13534217
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