Črt Dragar (Author), Tanja Potrč (Author), Sebastjan Nemec (Author), Robert Roškar (Author), Stane Pajk (Author), Petra Kocbek (Author), Slavko Kralj (Author)

Abstract

The development of various magnetically-responsive nanostructures is of great importance in biomedicine. The controlled assembly of many small superparamagnetic nanocrystals into large multi-core clusters is needed for effective magnetic drug delivery. Here, we present a novel one-pot method for the preparation of multi-core clusters for drug delivery (i.e., magnetic nanocarriers). The method is based on hot homogenization of a hydrophobic phase containing a nonpolar surfactant into an aqueous phase, using ultrasonication. The solvent-free hydrophobic phase that contained tetradecan-1-ol, γ-Fe$_2$O$_3$ nanocrystals, orlistat, and surfactant was dispersed into a warm aqueous surfactant solution, with the formation of small droplets. Then, a pre-cooled aqueous phase was added for rapid cooling and the formation of solid magnetic nanocarriers. Two different nonpolar surfactants, polyethylene glycol dodecyl ether (B4) and our own N$^1$,N$^1$-dimethyl-N$^2$-(tricosan-12-yl)ethane-1,2-diamine (SP11), were investigated for the preparation of MC-B4 and MC-SP11 magnetic nanocarriers, respectively. The nanocarriers formed were of spherical shape, with mean hydrodynamic sizes <160 nm, good colloidal stability, and high drug loading (7.65 wt.%). The MC-B4 nanocarriers showed prolonged drug release, while no drug release was seen for the MC-SP11 nanocarriers over the same time frame. Thus, the selection of a nonpolar surfactant for preparation of magnetic nanocarriers is crucial to enable drug release from nanocarrier.

Keywords

magnetic nanocrystals;magnetic drug delivery;nanocarriers;multi-core particles;magnetic nanoparticles;drug release;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UL FFA - Faculty of Pharmacy
UDC: 620.3
COBISS: 32095527 Link will open in a new window
ISSN: 1996-1944
Views: 242
Downloads: 65
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Other data

Type (COBISS): Article
Pages: str. 540-1-540-14
Volume: ǂVol. ǂ12
Issue: ǂno. ǂ3
Chronology: 2019
DOI: 10.3390/ma12030540
ID: 13659376