Tomaž Mark Zorec (Author), Denis Kutnjak (Author), Lea Hošnjak (Author), Blanka Kušar (Author), Katarina Trčko (Author), Boštjan Kocjan (Author), Yu Li (Author), Miljenko Križmarić (Author), Jovan Miljković (Author), Maja Ravnikar (Author), Mario Poljak (Author)

Abstract

Molluscum contagiosum virus (MCV) is the sole member of the Molluscipoxvirus genus and the causative agent of molluscum contagiosum (MC), a common skin disease. Although it is an important and frequent human pathogen, its genetic landscape and evolutionary history remain largely unknown. In this study, ten novel complete MCV genome sequences of the two most common MCV genotypes were determined (five MCV1 and five MCV2 sequences) and analyzed together with all MCV complete genomes previously deposited in freely accessible sequence repositories (four MCV1 and a single MCV2). In comparison to MCV1, a higher degree of nucleotide sequence conservation was observed among MCV2 genomes. Large-scale recombination events were identified in two newly assembled MCV1 genomes and one MCV2 genome. One recombination event was located in a newly identified recombinant region of the viral genome, and all previously described recombinant regions were re-identified in at least one novel MCV genome. MCV genes comprising the identified recombinant segments have been previously associated with viral interference with host T-cell and NK-cell immune responses. In conclusion, the two most common MCV genotypes emerged along divergent evolutionary pathways from a common ancestor, and the differences in the heterogeneity of MCV1 and MCV2 populations may be attributed to the strictness of the constraints imposed by the host immune response.

Keywords

molluscum contagiosum virus;complete genome;recombination;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UL MF - Faculty of Medicine
UDC: 616.9
COBISS: 34025433 Link will open in a new window
ISSN: 1999-4915
Views: 158
Downloads: 54
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Other data

Secondary language: Slovenian
Secondary keywords: virus molluscum contagiosum;popolni genom;rekombinacija;
Type (COBISS): Article
Pages: str. 1-24
Volume: ǂVol. ǂ10
Issue: ǂiss. ǂ11
Chronology: 2018
DOI: 10.3390/v10110586
ID: 13682532