nanomaterials in brain cancer research, diagnosis and therapy
Alja Zottel (Author), Alja Videtič (Author), Ivana Jovchevska (Author)

Abstract

Advances in technology of the past decades led to development of new nanometer scale diagnosis and treatment approaches in cancer medicine leading to establishment of nanooncology. Inorganic and organic nanomaterials have been shown to improve bioimaging techniques and targeted drug delivery systems. Their favorable physico-chemical characteristics, like small sizes, large surface area compared to volume, specific structural characteristics, and possibility to attach different molecules on their surface transform them into excellent transport vehicles able to cross cell and/or tissue barriers, including the blood-brain barrier. The latter is one of the greatest challenges in diagnosis and treatment of brain cancers. Application of nanomaterials can prolong the circulation time of the drugs and contrasting agents in the brain, posing an excellent opportunity for advancing the treatment of the most aggressive form of the brain cancer-glioblastomas. However, possible unwanted side-effects and toxicity issues must be considered before final clinical translation of nanoparticles.

Keywords

nanomateriali;rak možganov;nanomedicina;nanomaterials;brain cancer;nanomedicine;

Data

Language: English
Year of publishing:
Typology: 1.02 - Review Article
Organization: UL MF - Faculty of Medicine
UDC: 616-006
COBISS: 34313945 Link will open in a new window
ISSN: 1996-1944
Views: 258
Downloads: 111
Average score: 0 (0 votes)
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Other data

Secondary language: Slovenian
Secondary keywords: nanomateriali;rak možganov;nanomedicina;
Type (COBISS): Article
Pages: str. 1-28
Volume: ǂVol. ǂ12
Issue: ǂno. ǂ10
Chronology: 2019
DOI: 10.3390/ma12101588
ID: 13715167
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