ǂThe ǂquest for genetic risk factors for Crohn's disease in the post-GWAS era

Karin Fransen (Author), Mitja Mitrovič (Author), Cleo C van Diemen (Author), Rinse K. Weersma (Author)

Abstract

Multiple genome-wide association studies (GWASs) and two large scale meta-analyses have been performed for Crohn's disease and have identified 71 susceptibility loci. These findings have contributed greatly to our current understanding of the disease pathogenesis. Yet, these loci only explain approximately 23% of the disease heritability. One of the future challenges inthis post-GWAS era is to identify potential sources of the remaining heritability. Such sources may include common variants with limited effect size, rare variants with higher effect sizes, structural variations, or even more complicated mechanisms such as epistatic, gene-environment and epigeneticinteractions. Here, we outline potential sources of this hidden heritability, focusing on Crohn's disease and the currently available data. Wealso discuss future strategies to determine more about the heritability; these strategies include expanding current GWAS, fine-mapping, whole genome sequencing or exome sequencing, and using family-based approaches. Despite thecurrent limitations, such strategies may help to transfer research achievements into clinical practice and guide the improvement of preventive and therapeutic measures.

Keywords

genetic risk factors;Crohn’s disease;

Data

Language:	English
Year of publishing:	2011
Typology:	1.02 - Review Article
Organization:	UM MF - Faculty of Medicine
UDC:	616.344:577
COBISS:	512172600
ISSN:	1756-994X
Views:	1899
Downloads:	211
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	Slovenian
Secondary keywords:	Crohn Disease;genetics;Crohnova bolezen;Genetika;
URN:	URN:SI:UM:
Type (COBISS):	Scientific work
Pages:	10 str.
Volume:	Vol. 3
Issue:	iss. 2
Chronology:	2011
Keywords (UDC):	applied sciences;medicine;technology;uporabne znanosti;medicina;tehnika;medical sciences;medicina;pathology;clinical medicine;patologija;klinična medicina;pathology of the digestive system;complaints of the alimentary canal;bolezni prebavil;gastroenterologija;mathematics;natural sciences;naravoslovne vede;matematika;biological sciences in general;biologija;material bases of life;biochemistry;molecular biology;biophysics;biokemija;molekularna biologija;biofizika;
DOI:	10.1186/gm227
ID:	13862