Treatment patterns, testing practices, and outcomes in the pre-FLAURA era for patients with EGFR mutation-positive advanced NSCLC
ǂa ǂretrospective chart review (REFLECT)
Abstract
Background. Immunotherapy with immune checkpoint inhibitors (ICIs) recently became the standard treatment for patients with advanced non-small cell lung cancer (NSCLC). Here, we present the first results of a real-world observational study on the effectiveness of ICI monotherapy in patients with advanced NSCLC treated at a single academic center in a Central and Eastern European (CEE) country. Materials and methods. Overall, 66 consecutive patients with advanced NSCLC treated with ICIs in everyday clinical practice, either with first-line pembrolizumab (26 patients) or second-line atezolizumab, nivolumab, or pembrolizumab (40 patients), from August 2015 to November 2018, were included. All data were retrieved from a hospital lung cancer registry, in which the data is collected prospectively. Results. Included patients had a median age of 64 years, most were male (55%), 6% were in performance status >/=2, and 18% had controlled central nervous system metastases at baseline. In first-line, the median progression-free survival (mPFS) was 9.3 months, while the median overall survival (mOS) was not reached. The 1-year overall survival (OS) was 62%. In second-line, the mPFS and mOS were 3.5 months and 9.9 months, respectively, with a 1-year OS of 35%. In the overall population, adverse events of any grade were recorded in 79% of patients and of severe grade (3-4) in 12% of patients. Conclusion. The first real-world outcomes of NSCLC immunotherapy from a CEE country suggest comparable effectiveness to those observed in clinical trials and other real-world series, mainly coming from North America and Western European countries. Further data to inform on the real-world effectiveness of immunotherapy worldwide are needed.
Keywords
napredovali nedrobnocelinčni karcinom pljuč;podatki iz resničnega življenja;srednja Evropa;advanced non-small cell lung cancer;real-world data;Central Europe;
Data
| Language: | English |
|---|---|
| Year of publishing: | 2021 |
| Typology: | 1.01 - Original Scientific Article |
| Publisher: | Sage |
| UDC: | 616-006 |
| COBISS: |
89318403
|
| ISSN: | 1758-8359 |
| Views: | 286 |
| Downloads: | 94 |
| Average score: | 0 (0 votes) |
| Metadata: |
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Other data
| Secondary keywords: | Carcinoma, non-small cell lung;Immunotherapy;Nedrobnocelični karcinom pljuč;Imunoterapija;Europe;Europe, Eastern;Evropa;Vzhodna Evropa; |
|---|---|
| Source comment: | Nasl. z nasl. zaslona; Soavtorica iz Slovenije: Urška Janžič; Opis vira z dne 14. 12. 2021; |
| Pages: | str. 1-11 |
| Issue: | ǂVol. ǂ13 |
| Chronology: | 2021 |
| DOI: | 10.1177/17588359211059874 |
| ID: | 13961696 |
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