Sarka Salajkova (Author), Marketa Benkova (Author), Jan Marek (Author), Radek Sleha (Author), Lukas Prchal (Author), David Malinak (Author), Rafael Dolezal (Author), Kristina Sepčić (Author), Nina Gunde-Cimerman (Author), Kamil Kuca (Author), Ondrej Soukup (Author)

Abstract

Nosocomial infections, which greatly increase morbidity among hospitalized patients, together with growing antibiotic resistance still encourage many researchers to search for novel antimicrobial compounds. Picolinium salts with different lengths of alkyl chains (C$_{12}$, C$_{14}$, C$_{16}$) were prepared by Menshutkin-like reaction and evaluated with respect to their biological activity, i.e., lipophilicity and critical micellar concentration. Picolinium salts with C$_{14}$ and C$_{16}$ side chains achieved similar or even better results when in terms of antimicrobial efficacy than benzalkoniums; notably, their fungicidal efficiency was substantially more potent. The position of the methyl substituent on the aromatic ring does not seem to affect antimicrobial activity, in contrast to the effect of length of the N-alkyl chain. Concurrently, picolinium salts exhibited satisfactory low cytotoxicity against mammalian cells, i.e., lower than that of benzalkonium compounds, which are considered as safe.

Keywords

pikolinijeve soli;kvartarne amonijeve spojine;surfaktant;kritična micelarna koncentracija;protimikrobna aktivnost;citotoksičnost;picolinium salts;quaternary ammonium compounds;surfactant;critical micellar concentration;antimicrobial activity;cytotoxicity;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UL BF - Biotechnical Faculty
UDC: 577
COBISS: 14885123 Link will open in a new window
ISSN: 1420-3049
Views: 162
Downloads: 60
Average score: 0 (0 votes)
Metadata: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Other data

Secondary language: Slovenian
Secondary keywords: pikolinijeve soli;kvartarne amonijeve spojine;surfaktant;kritična micelarna koncentracija;protimikrobna aktivnost;citotoksičnost;
Type (COBISS): Article
Pages: str. 1-16
Volume: 25
Issue: 2254
Chronology: 2020
DOI: 10.3390/molecules25092254
ID: 14083833