Jernej Kmetec (Author), Urška Kuhar (Author), Aleksandra Grilc Fajfar (Author), Diana Žele (Author), Gorazd Vengušt (Author)

Abstract

Papillomaviruses (PVs) are an extremely large group of viruses that cause skin and mucosa infections in humans and various animals. In roe deer and red deer, most PVs belong to the Deltapapillomavirus genus and cause neoplastic changes that are generally described as fibropapillomas. Despite the wide distribution of roe and red deer throughout Europe and beyond, the data in the scientific literature regarding the widespread distribution of PVs and the genetic variability of PV genomes in these species are rather scarce. This study describes cutaneous fibropapillomatosis cases in roe and red deer with clinical manifestations that are typical of infections with PVs. In all cases, the presence of PV DNA was confirmed using PCR, followed by Sanger sequencing of the partial L1 gene. The complete PV genomes were determined in all the investigated samples using next-generation sequencing technology, revealing infections of roe deer with the CcaPV1-type and red deer with the CePV1v-type variant. A comparison of the complete CcaPV1-type and CePV1v-type variant genome sequences reported here with already available complete genome sequences in GenBank revealed their great genetic stability across time and space.

Keywords

papillomavirus;fibropapillomatosis;red deer;roe deer;genome;NGS;Papillomaviridae;deer;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UL VF - Veterinary Faculty
UDC: 578
COBISS: 27616515 Link will open in a new window
ISSN: 1999-4915
Views: 155
Downloads: 54
Average score: 0 (0 votes)
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Other data

Secondary keywords: Papillomaviridae;Genome;Deer;
Type (COBISS): Article
Pages: str. 1-14
Volume: ǂVol. ǂ12
Issue: ǂno. ǂ9
Chronology: 2020
DOI: 10.3390/v12091001
ID: 14229724