Vojko Berce (Author), Uroš Potočnik (Author)

Abstract

Med posamezniki obstajajo velike razlike v učinku protiastmatične terapije, ki so pogojene predvsem z različnim genetskim zapisom. Namen farmakogenomike je poiskati tiste polimorfizme, ki so povezani z vsemi učinki določenega zdravila. Farmakogenomika pri astmi zaenkrat proučuje predvsem vpliv genov, ki kodirajo receptorje za zdravila, komponente postreceptorske signalne transdukcije in transkripcijske dejavnike. Največ raziskav je bilo narejenih na področju farmakogenomike beta2 agonistov. Mutacija Arg/Arg na mestu 16 gena ADRB2, ter mutacije v genih LTC4S, ALOX5 in CRHR1 spremenijo odziv na protiastmatično terapijo. Cilj farmakogenomike astme pa je poiskati čimbolj učinkovito protiastmatično zdravilo z čimmanj stranskimi učinki individualno za vsakega posameznika na podlagi njegovega genotipa.

Keywords

farmakogenomika;astma;polimorfizmi;

Data

Language: Slovenian
Year of publishing:
Typology: 1.02 - Review Article
Organization: UM FKKT - Faculty of Chemistry and Chemical Engineering
Publisher: Slovensko farmacevtsko društvo
UDC: 575.111:616.248
COBISS: 12895766 Link will open in a new window
ISSN: 0014-8229
Parent publication: Farmacevtski vestnik
Views: 2216
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Other data

Secondary language: English
Secondary title: Pharmacogenomics in asthma treatment
Secondary abstract: There are substantial differences in the effect of antiasthmatic therapy between individuals which are dependent on the diversity of the genetic code. The purpose of pharmacogenomics is to find out those polymorphisms, which are connected with all effects of certain drug. For now the pharmacogenomics of asthma above all study the influence of the genes which code for drug receptors, signal transduction components and transcription factors. Most studies were done in the field of pharmacogenomics of beta2 agonists. Gene mutations that are known to alter the response to asthma therapy include Arg/Arg at position 16 in ADRB2 gene, mutations of LTC4S and ALOX5 and CRHR1 variants. The goal of pharmacogenomics is to find out most efficient drug without adverse side effects individually suited for each patient on basis of his genotype.
Secondary keywords: pharmacogenomics;asthma;polymorphisms;
URN: URN:NBN:SI
Pages: str. 303-306
Volume: ǂLetn. ǂ59
Issue: ǂšt. ǂ6
Chronology: dec. 2008
Keywords (UDC): mathematics;natural sciences;naravoslovne vede;matematika;biological sciences in general;biologija;general genetics;general cytogenetics;splošna genetika;splošna citogenetika;applied sciences;medicine;technology;uporabne znanosti;medicina;tehnika;medical sciences;medicina;pathology;clinical medicine;patologija;klinična medicina;pathology of the respiratory system;complaints of the respiratory organs;bolezni dihal;
ID: 1437608