Witold Musiał (Author), Vanja Kokol (Author), Bojana Vončina (Author)

Abstract

The solubility of chlorhexidine is highly dependent on the salt present in solution. The aim of present research was evaluation of the effect of two polymers: polyacrylic acid and methylcellulose on the pH of resulting preparation, containing chlorhexidine. Also the solubility aspect was considered in the discussion, as an helpful issue in development in drug form technology. Preparations of chlorhexidine with methylcellulose are characterized by high pH in the range between 9,70-9,98 depending on the temperature of measurements. For preparations of chlorhexidine and polyacrylic acid pH of 5,31-5,72 was evaluated, which was near the physiological values of skin pH. The polyacrylic acid acts as a buffer and enables maintaining of pH near to physiological values. As the connection between polyacrylic acid and chlorhexidine seems to be strong, respective assessments of antimicrobial activity should be performed, to evaluate the applicative value of the preparations.

Keywords

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Data

Language: Polish
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UM FS - Faculty of Mechanical Engineering
UDC: 677.017:543
COBISS: 14721558 Link will open in a new window
ISSN: 0370-0747
Views: 1114
Downloads: 18
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Other data

Secondary language: English
Secondary title: ǂThe ǂinfluence of anionic and non-ionic polymer on adjustment of pH of chlorhexidine preparation including respective solubility aspect
Secondary abstract: The solubility of chlorhexidine is highly dependent on the salt present in solution. The aim of present research was evaluation of the effect of two polymers: polyacrylic acid and methylcellulose on the pH of resulting preparation, containing chlorhexidine. Also the solubility aspect was considered in the discussion, as an helpful issue in development in drug form technology. Preparations of chlorhexidine with methylcellulose are characterized by high pH in the range between 9,70-9,98 depending on the temperature of measurements. For preparations of chlorhexidine and polyacrylic acid pH of 5,31-5,72 was evaluated, which was near the physiological values of skin pH. The polyacrylic acid acts as a buffer and enables maintaining of pH near to physiological values. As the connection between polyacrylic acid and chlorhexidine seems to be strong, respective assessments of antimicrobial activity should be performed, to evaluate the applicative value of the preparations.
Secondary keywords: polyacrylic acid;methylcellulose;chlorhexidine;skin surface;solubility;pH;
URN: URN:SI:UM:
Pages: str. 37-45
Volume: ǂT. ǂ40
Issue: ǂno. ǂ1
Chronology: 2010
Keywords (UDC): applied sciences;medicine;technology;uporabne znanosti;medicina;tehnika;various industries;trades and crafts;razne industrije;obrti in rokodelstva;textile industry;tekstilna industrija;mathematics;natural sciences;naravoslovne vede;matematika;chemistry;crystallography;mineralogy;kemija;analytical chemistry;analizna kemija;
ID: 1438855