ǂA ǂfacile route to the synthesis of coated maghemite nanocomposites for hyperthermia applications

Gregor Ferk (Author), Irena Ban (Author), Janja Stergar (Author), Darko Makovec (Author), Anton Hamler (Author), Zvonko Jagličić (Author), Mihael Drofenik (Author)

Abstract

CM-dextran-covered maghemite particles for applications in magnetic hyperthermia treatments were synthesized and their physical, magnetic and morphological properties were examined. Magnetic fluids were prepared and their heating proper ies in an alternating magnetic field were studied. The results reveal that the particle size and the thickness of the carboxy-methyl-dextran (CM-dextran) coatings have a decisive influence on the heating properties: specific absorption rate (SAR). The majority of the magnetic dissipation comes from the Neel relaxation, while the Brown contribution is small. A thermal steady state at the selected temperature (42 °C) can be achieved using synthesized maghemite particles with proper particle morphology and by controlling the magnetic field intensity or the frequency.

Keywords

magnetic nanoparticles;hyperthermia;magnetic properties;

Data

Language:	English
Year of publishing:	2012
Typology:	1.01 - Original Scientific Article
Organization:	UM FKKT - Faculty of Chemistry and Chemical Engineering
UDC:	544.163
COBISS:	16097046
ISSN:	1318-0207
Views:	1405
Downloads:	84
Average score:	0 (0 votes)
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Other data

Secondary language:	Slovenian
Secondary abstract:	V prispevku je predstav ljena sinteza in karakterizacija magnetnih maghemitnih nanodelcev prevlečenih s karboksimetil dekstranom (CM-dekstran), primernih za uporabo v magnetni hipertermiji. Stopnjo specifične absorpcije (SAR) stabilne magnetne tekočine pripravljene iz maghemitnih nanodelcev prevlečenih s CM-dekstranom, smo preverili s pomočjo kalorimetričnih meritev magnetne tekočine izpostavljene zunanjemu izmeničnemu magnetnem polju. Rezultati kažejo, da velikost magnetnih nanodelcev in debelina prevleke CM-dekstrana vplivata na stopnjo specifične absorpcije (SAR), pri čemer večji del toplotnih izgub izhaja iz Neel-ove relaksacije, medtem ko je prispevek Brown-ove relaksacije majhen. Termično ravnotežje pri ciljni temperaturi (42 °C) lahko dosežemo s primernimi morfološkimi lastnostmi sintetiziranih magnetnih nanodelcev maghemita in s kontroliranjem jakosti ali frekvence zunanjega izmeničnega magnetnega polja.
Secondary keywords:	magnetni nanodelci;hipertermija;magnetne lastnosti;
URN:	URN:NBN:SI
Type (COBISS):	Scientific work
Pages:	str. 366-374
Volume:	ǂVol. ǂ59
Issue:	ǂno. ǂ2
Chronology:	2012
Keywords (UDC):	mathematics;natural sciences;naravoslovne vede;matematika;chemistry;crystallography;mineralogy;kemija;physical chemistry;fizikalna kemija;chemical structure of matter;kemijska struktura snovi;
ID:	1439082