Tom Turk (Author), Jerneja Ambrožič (Author), Urška Batista (Author), Gašper Strugar (Author), Rok Kosmina (Author), Sandra Čivović (Author), Dorte Janussen (Author), Silke Kauferstein (Author), Dietrich Mebs (Author), Kristina Sepčić (Author)

Abstract

We report on the screening of ethanolic extracts from 33 deep-sea Antarctic marine sponges for different biological activities. We monitored hemolysis, inhibition of acetylcholinesterase, cytotoxicity towards normal and transformed cells and growth inhibition of laboratory, commensal and clinically and ecologically relevant bacteria. The most prominent activities were associated with the extracts from sponges belonging to the genus Latrunculia, which show all of these activities. While most of these activities are associated to already known secondary metabolites, the extremely strong acetylcholinesterase inhibitory potential appears to be related to a compound unknown to date. Extracts from Tetilla leptoderma, Bathydorus cf. spinosus, Xestospongia sp., Rossella sp., Rossella cf. racovitzae and Halichondria osculum were hemolytic, with the last two also showing moderate cytotoxic potential. The antibacterial tests showed significantly greater activities of the extracts of these Antarctic sponges towards ecologically relevant bacteria from sea water and from Arctic ice. This indicates their ecological relevance for inhibition of bacterial microfouling.

Keywords

Antarctic marine sponges;hemolysis;antibacterial activity;cytotoxicity;acetylcholinesterase inhibition;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UL BF - Biotechnical Faculty
UDC: 577.1
COBISS: 2762319 Link will open in a new window
ISSN: 1660-3397
Views: 828
Downloads: 457
Average score: 0 (0 votes)
Metadata: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Other data

Type (COBISS): Article
Pages: str. 1126-1139
Volume: ǂVol. ǂ11
Issue: ǂno. ǂ4
Chronology: 2013
DOI: 10.3390/md11041126
ID: 1446936