Glucagon-like peptide 1 and taste perception

from molecular mechanisms to potential clinical implications

Mojca Jensterle Sever (Author), Manfredi Rizzo (Author), Andrej Janež (Author)

Abstract

Preclinical studies provided some important insights into the action of glucagon-like peptide 1 (GLP-1) in taste perception. This review examines the literature to uncover some molecular mechanisms and connections between GLP-1 and the gustatory coding. Local GLP-1 production in the taste bud cells, the expression of GLP-1 receptor on the adjacent nerves, a functional continuum in the perception of sweet chemicals from the gut to the tongue and an identification of GLP-1 induced signaling pathways in peripheral and central gustatory coding all strongly suggest that GLP-1 is involved in the taste perception, especially sweet. However, the impact of GLP-1 based therapies on gustatory coding in humans remains largely unaddressed. Based on the molecular background we encourage further exploration of the tongue as a new treatment target for GLP-1 receptor agonists in clinical studies. Given that pharmacological manipulation of gustatory coding may represent a new potential strategy against obesity and diabetes, the topic is of utmost clinical relevance.

Keywords

glukagonu podoben peptid 1 (GLP-1);okus;jezik;debelost;sladko;glucagon-like peptide 1 (GLP-1);taste;tongue;obesity;sweet;

Data

Language:	English
Year of publishing:	2021
Typology:	1.02 - Review Article
Organization:	UL MF - Faculty of Medicine
UDC:	616.379
COBISS:	47378691
ISSN:	1422-0067
Views:	164
Downloads:	43
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	Slovenian
Secondary keywords:	glukagonu podoben peptid 1 (GLP-1);okus;jezik;debelost;sladko;
Type (COBISS):	Article
Pages:	str. 1-13
Volume:	ǂVol. ǂ22
Issue:	ǂiss. ǂ2
Chronology:	2021
DOI:	10.3390/ijms22020902
ID:	14527786