from molecular mechanisms to potential clinical implications
Mojca Jensterle Sever (Author), Manfredi Rizzo (Author), Andrej Janež (Author)

Abstract

Preclinical studies provided some important insights into the action of glucagon-like peptide 1 (GLP-1) in taste perception. This review examines the literature to uncover some molecular mechanisms and connections between GLP-1 and the gustatory coding. Local GLP-1 production in the taste bud cells, the expression of GLP-1 receptor on the adjacent nerves, a functional continuum in the perception of sweet chemicals from the gut to the tongue and an identification of GLP-1 induced signaling pathways in peripheral and central gustatory coding all strongly suggest that GLP-1 is involved in the taste perception, especially sweet. However, the impact of GLP-1 based therapies on gustatory coding in humans remains largely unaddressed. Based on the molecular background we encourage further exploration of the tongue as a new treatment target for GLP-1 receptor agonists in clinical studies. Given that pharmacological manipulation of gustatory coding may represent a new potential strategy against obesity and diabetes, the topic is of utmost clinical relevance.

Keywords

glukagonu podoben peptid 1 (GLP-1);okus;jezik;debelost;sladko;glucagon-like peptide 1 (GLP-1);taste;tongue;obesity;sweet;

Data

Language: English
Year of publishing:
Typology: 1.02 - Review Article
Organization: UL MF - Faculty of Medicine
UDC: 616.379
COBISS: 47378691 Link will open in a new window
ISSN: 1422-0067
Views: 164
Downloads: 43
Average score: 0 (0 votes)
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Other data

Secondary language: Slovenian
Secondary keywords: glukagonu podoben peptid 1 (GLP-1);okus;jezik;debelost;sladko;
Type (COBISS): Article
Pages: str. 1-13
Volume: ǂVol. ǂ22
Issue: ǂiss. ǂ2
Chronology: 2021
DOI: 10.3390/ijms22020902
ID: 14527786