Polynuclear silver(I) complex with thianthrene

structural characterization, antimicrobial activity and interaction with biomolecules

Darko P. Ašanin (Author), Tina P. Andrejević (Author), Sanja Skaro-Bogojevic (Author), Nevena Lj. Stevanović (Author), Ivana Aleksić (Author), Dušan Milivojević (Author), Franc Perdih (Author), Iztok Turel (Author), Miloš I. Djuran (Author), Biljana Đ. Glišić (Author)

Abstract

New silver(I) complex with thianthrene (tia), [Ag(NO$_3$)(tia)(H$_2$O)]$_n$, was synthesized by the reaction of AgNO$_3$ with an equimolar amount of tia in ethanol/dichloromethane (v/v 1:1) at room temperature, and characterized by NMR, IR and UV-Vis spectroscopy and single-crystal X-ray diffraction analysis. The antimicrobial activity of the synthesized complex was evaluated against the broad panel of Gram-positive and Gram-negative bacteria and Candida spp. This complex showed significant activity toward important human pathogens Gram-positive Staphylococcus aureus and Candida parapsilosis with minimal inhibitory concentrations (MICs) being 3.91 µg/mL. The interaction of [Ag(NO$_3$)(tia)(H$_2$O)]$_n$ with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) was studied to evaluate the binding affinity towards these biomolecules for possible insights on the mode of antimicrobial activity. The binding affinity of the investigated complex to BSA is higher than that for DNA, indicating that proteins could be more favorable binding sites for this complex in comparison to the nucleic acids.

Keywords

srebro;srebrovi kompleksi;protimikrobno delovanje;interakcije z biomolekulami;

Data

Language:	English
Year of publishing:	2020
Typology:	1.08 - Published Scientific Conference Contribution
Organization:	UL FKKT - Faculty of Chemistry and Chemical Technology
UDC:	546.57
COBISS:	44168195
ISSN:	2504-3900
Views:	126
Downloads:	51
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	Slovenian
Secondary keywords:	srebro;srebrovi kompleksi;protimikrobno delovanje;interakcije z biomolekulami;
Type (COBISS):	Article
Pages:	str. 1-7
Volume:	ǂVol. ǂ67
Issue:	ǂiss. ǂ1
Chronology:	2020
DOI:	10.3390/ASEC2020-07534
ID:	14545325