Novel GRHL2 gene variant associated with hearing loss
ǂa ǂcase report and review of the literature
Abstract
In contrast to the recessive form, hearing loss inherited in a dominant manner is more often post-lingual and typically results in a progressive sensorineural hearing loss with variable severity and late onset. Variants in the GRHL2 gene are an extremely rare cause of dominantly inherited hearing loss. Genetic testing is a crucial part of the identification of the etiology of hearing loss in individual patients, especially when performed with next-generation sequencing, enabling simultaneous analysis of numerous genes, including those rarely associated with hearing loss. We aimed to evaluate the genetic etiology of hearing loss in a family with moderate late-onset hearing loss using next-generation sequencing and to conduct a review of reported variants in the GRHL2 gene. We identified a novel disease-causing variant in the GRHL2 gene (NM_024915: c.1510C>T; p.Arg504Ter) in both affected members of the family. They both presented with moderate late-onset hearing loss with no additional clinical characteristics. Reviewing known GRHL2 variants associated with hearing loss, we can conclude that they are more likely to be truncating variants, while the associated onset of hearing loss is variable.
Keywords
autosomal-dominant hearing loss;next-generation sequencing;GRHL2 gene;
Data
| Language: | English |
|---|---|
| Year of publishing: | 2021 |
| Typology: | 1.02 - Review Article |
| Organization: | UL MF - Faculty of Medicine |
| UDC: | 616.21 |
| COBISS: |
57531139
|
| ISSN: | 2073-4425 |
| Views: | 134 |
| Downloads: | 39 |
| Average score: | 0 (0 votes) |
| Metadata: |
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Other data
| Secondary language: | Slovenian |
|---|---|
| Secondary keywords: | avtosomno-dominantna izguba sluha;zaporedje naslednje generacije;gen GRHL2; |
| Type (COBISS): | Article |
| Pages: | str. 1-8 |
| Volume: | ǂVol. ǂ12 |
| Issue: | ǂno. ǂ4 |
| Chronology: | 2021 |
| DOI: | 10.3390/genes12040484 |
| ID: | 14641683 |
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