Vitamin A and retinoids in bladder cancer chemoprevention and treatment

ǂa ǂnarrative review of current evidence, challenges and future prospects

Larisa Tratnjek (Author), Jera Jeruc (Author), Rok Romih (Author), Daša Zupančič (Author)

Abstract

Bladder cancer (BC) is the tenth most common cancer worldwide with a high recurrence rate, morbidity and mortality. Therefore, chemoprevention and improved treatment of BC are of paramount importance. Epidemiological studies suggest that adequate vitamin A intake may be associated with reduced BC risk. In addition, retinoids, natural and synthetic derivatives of vitamin A, are intensively studied in cancer research due to their antioxidant properties and their ability to regulate cell growth, differentiation, and apoptosis. Findings from in vivo and in vitro models of BC show great potential for the use of retinoids in the chemoprevention and treatment of BC. However, translation to the clinical practice is limited. In this narrative review we discuss: (i) vitamin A and retinoid metabolism and retinoic acid signalling, (ii) the pathobiology of BC and the need for chemoprevention, (iii) the epidemiological evidence for the role of dietary vitamin A in BC, (iv) mechanistic insights obtained from in vivo and in vitro models, (v) clinical trials of retinoids and the limitations of retinoid use, (vi) novel systems of retinoid delivery, and (vii) components of retinoid signalling pathways as potential novel therapeutic targets.

Keywords

bladder cancer;vitamin A;retinoic acid signalling;

Data

Language:	English
Year of publishing:	2021
Typology:	1.02 - Review Article
Organization:	UL MF - Faculty of Medicine
UDC:	617.7
COBISS:	57932035
ISSN:	1422-0067
Views:	163
Downloads:	43
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	Slovenian
Secondary keywords:	rak mehurja;vitamin A;signalizacija retinojske kisline;
Type (COBISS):	Article
Pages:	str. 1-19
Volume:	ǂVol. ǂ22
Issue:	ǂiss. ǂ7
Chronology:	2021
DOI:	10.3390/ijms22073510
ID:	14641690