Josip Radić (Author), Maša Buljac (Author), Boštjan Genorio (Author), Ema Gričar (Author), Mitja Kolar (Author)

Abstract

A novel promising carbon paste electrode with excellent potentiometric properties was prepared for the analysis of trihexyphenidyl hydrochloride (THP), the acetylcholine receptor and an anticholinergic drug in real samples. It contains 10.2% trihexyphenidy-tetraphenylborate ionic pair as the electroactive material, with the addition of 3.9% reduced graphene oxide and 0.3% of anionic additive into the paste, which consists of 45.0% dibutylphthalate as the solvent mediator and 40.6% graphite. Under the optimized experimental conditions, the electrode showed a Nernstian slope of 58.9 ± 0.2 mV/decade with a regression coefficient of 0.9992. It exhibited high selectivity and reproducibility as well as a fast and linear dynamic response range from 4.0 × 10$^{−7}$ to 1.0 × 10$^{−2}$ M. The electrode remained usable for up to 19 days. Analytical applications showed excellent recoveries ranging from 96.8 to 101.7%, LOD was 2.5 × 10$^{−7}$ M. The electrode was successfully used for THP analysis of pharmaceutical and biological samples.

Keywords

potenciometrija;elektrode iz ogljikove paste;reduciran grafen oksid;triheksifenidil hidroklorid;farmacevtske učinkovine;urinski vzorci;potentiometry;carbon paste electrode;reduced graphene oxide;trihexyphenidyl hydrochloride;pharmaceuticals;urine samples;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UL FKKT - Faculty of Chemistry and Chemical Technology
UDC: 543.554
COBISS: 61633027 Link will open in a new window
ISSN: 1424-8220
Views: 203
Downloads: 63
Average score: 0 (0 votes)
Metadata: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Other data

Secondary language: Slovenian
Secondary keywords: potenciometrija;elektrode iz ogljikove paste;reduciran grafen oksid;triheksifenidil hidroklorid;farmacevtske učinkovine;urinski vzorci;
Type (COBISS): Article
Pages: str. 1-14
Volume: ǂVol. ǂ21
Issue: ǂiss. ǂ9
Chronology: May 2021
DOI: 10.3390/s21092955
ID: 14696230